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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
476-66-4
- 规格：
10 mM * 1 mL/500 mg/1 g/5 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥500.0 |
| 规格： | 1 g | 产品价格： | ￥700.0 |
| 规格： | 5 g | 产品价格： | ￥2200.0 |
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Ellagic acid
CAS No. : 476-66-4
MCE 国际站：Ellagic acid
产品活性：Ellagic acid 是一种天然的抗氧化剂，为有效的，ATP 竞争性的 CK2 抑制剂，IC50 和 Ki 值分别为 40 nM 和 20 nM。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点：Casein Kinase | Reactive Oxygen Species | Endogenous Metabolite
In Vitro: Ellagic acid is a potent CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. Ellagic acid also blocks other kinases such as LYN, PKA, SYK, GSK3, FGR and CK1, with IC50s of 2.9, 3.5, 4.3, 7.5, 9.4 and 13.0 μM, respectively, and shows no obvious effects on DYRK1a, CSK, NPM-ALK, RET and FLT3 (IC50s > 40 μM). Ellagic acid (5-100 μM) shows inhibitory activities against Karpas299, SUDHL1, SR786, and FE-PD cell lines. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells.
In Vivo: Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats.
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α -羟基丙酸。 L型（见图）为厌氧糖酵解的最终产物，是由乳酸脱氧酶的作用使丙酮酸还原而生成的。在激烈的肌肉运动时，乳酸在肌肉中积累，其一部分随血液流到肝脏，再合成为葡萄糖（糖的产生）。在乳酸菌的乳酸发酵和大肠杆菌、梭状芽胞杆菌属的混合有机酸发酵过程中也能大量形成乳酸，为酸乳酪（ yoghurt）和咸菜的酸味的主要成分。这里因生物种类不同，有时可产生 L型、 D型和外消旋体。在动物和微生物中是作为碳源而被利用的物质之一。
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