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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
FRG-8813
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
118288-08-7
- 规格：
10 mM * 1 mL/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥353.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥321.0 |
| 规格： | 25 mg | 产品价格： | ￥500.0 |
| 规格： | 50 mg | 产品价格： | ￥800.0 |
| 规格： | 100 mg | 产品价格： | ￥1200.0 |
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Lafutidine
CAS No. : 118288-08-7
MCE 国际站：Lafutidine
产品活性：Lafutidine (FRG-8813) 是一种组胺受体 H2RA 拮抗剂，具有胃粘膜保护作用。Lafutidine 可用于胃食管反流疾病的研究。
研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation
作用靶点：Histamine Receptor
In Vitro: Lafutidine exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect.
Lafutidine (0.1-10 µM) significantly augments the periarterial nerve stimulation (PNS, 1 Hz) induced-vasodilation in a concentration-dependent manner in rat perfused mesenteric vascular beds.
In Vivo: Lafutidine (3-30 mg/kg; p.o.; twice daily; for 6 days) dose-dependently reduces the severity of dextran sulfate Na (DSS)-induced colitis and significantly mitigates changes in the colon length and myeloperoxidase (MPO) activity.
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