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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
RC32
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2375555-66-9
- 规格：
1 mg
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FKBP12 PROTAC RC32
CAS No. : 2375555-66-9
MCE 国际站：FKBP12 PROTAC RC32
产品活性：FKBP12 PROTAC RC32 (RC32) 是基于 PROTAC 的有效 FKBP12 降解剂。FKBP12 PROTAC RC32 包含雷帕霉素 (Rapamycin；HY-10219) 和Cereblon E3 泛素连接酶配体 (Pomalidomide；HY-10984)。
研究领域：PROTAC | Autophagy | Apoptosis | Immunology/Inflammation
In Vitro: FKBP12 PROTAC RC32 (RC32; 0.1-1000 nM; for 12?hours) results in 50% protein degradation (DC50) of ~0.3?nM after only 12?hours of treatment.
In Vivo: RC32 (RC32; i.p.; 30?mg/kg; twice a day; 1 day) degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice.
?RC32 (orally; 60?mg/kg; twice a day; for 1 day) significantly degrades FKBP12 in mice.
?RC32 (i.p.; 8?mg/kg; twice a day; for 2 days) efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20?kg) .
?RC32 (i.p.; 8?mg/kg; twice a day; for 3 days) efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys.
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