Daun02,290304-24-4

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Daun02

CAS No. : 290304-24-4

MCE 国际站：Daun02

产品活性：Daun02是拓扑异构酶抑制剂Daunorubicin的前体。

研究领域：Cell Cycle/DNA Damage  |  Antibody-drug Conjugate/ADC Related

作用靶点：Topoisomerase  |  ADC Cytotoxin

In Vitro: Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca²⁺)-dependent action potentials in neuroblastoma cells. Daunorubicin is a topoisomerase inhibitor. Daun02 is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC₅₀) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively.

In Vivo: Daun02 is a good substrate for β-gal with K_m and V_max values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10^-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin.

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