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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃ to -80℃
- 保质期:
12个月
- 英文名:
Recombinant Cynomolgus / Rhesus CD137 / 4-1BB Protein (Fc Tag)
- 库存:
99
- 供应商:
北京义翘神州科技股份有限公司
- 规格:
20.00 µg/100.00 µg
| 规格: | 20.00 µg | 产品价格: | ¥980.0 |
|---|---|---|---|
| 规格: | 100.00 µg | 产品价格: | ¥2570.0 |
蛋白名称:CD137蛋白, CD137 protein
蛋白构建:A DNA sequence encoding the rhesus TNFRSF9 (NP_001253057.1) (Met1-Gln186) was expressed with the Fc region of human IgG1 at the C-terminus.
表达宿主:HEK293 Cells
蛋白纯度:> 95 % as determined by SDS-PAGE.
蛋白活性:1.Measured by its binding ability in a functional ELISA. 2.Immobilized rhesus TNFRSF9-Fc(Cat:90847-K02H) at 10μg/mL (100μL/well) can bind biotinylated human TNFSF9 (Cat:15693-H01H), the EC50 of biotinylated human TNFSF9 is 20-100ng/mL.
蛋白内毒素:< 1.0 EU per μg protein as determined by the LAL method.
预测N端:Leu 24
蛋白分子量:The recombinant rhesus TNFRSF9 consists of 401 amino acids and predicts a molecular mass of 44 kDa.
蛋白NP号:NP_001253057.1
蛋白氨基酸序列:Met1-Gln186
蛋白标签:C-human IgG1-Fc
蛋白保存条件:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验., and Wang, J. 2011. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat. Biotechnol. 29:1019‐1023.
T细胞识别机制另一个重要的进展是共刺激分子的研究。T细胞的活化除了上述识别条件外,还必须有共刺激分子(costimulator)参与。在T细胞激活诱导阶段缺乏共刺激信号,不仅不能活化T细胞,还会引起T细胞克隆特异性无反应性,导致免疫耐受。不同的细胞系统传递共刺激信号的分子有所不同。其中包括:B淋巴细胞激活抗原(B7)、细胞间粘附分子(ICAMs)、淋巴细胞功能相关抗原(LFA-3)、血管内皮粘附分子(VCAM-1)、热稳定抗原(HSA),以及近期发现的4-1BB等。它们与其相应的配体结合,发挥
Overview of Animal Models of Obesity
:273‐274. Guan, X.M., Yu, H., and Van der Ploeg, L.H. 1998. Evidence of altered hypothalamic pro‐opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice. Brain Res
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