Ginsenoside Rh2人参皂苷 Rh2,78214-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ginsenoside Rh2

CAS No. : 78214-33-2

MCE 国际站：Ginsenoside Rh2

产品活性：Ginsenoside Rh2 诱导 caspase-8 和 caspase-9 活化。Ginsenoside Rh2 以多途径方式诱导癌细胞凋亡。

研究领域：Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Caspase  |  Apoptosis  |  Endogenous Metabolite

结构分类：萜类  |  三萜

来源：植物  |  五加科  |  人参

In Vitro: Ginsenoside Rh2 induces the activation of two initiator caspases, caspase-8 and caspase-9 in human cancer cells. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner and is therefore a promising candidate for anti-tumor drug development. Ginsenoside Rh2 triggers p53-dependent Fas expression and consequent activation of caspase-8 and p53-independent caspase-9-mediated intrinsic pathway to cause cancer cell death.The cytotoxic activity of Ginsenoside Rh2 in the human tumor cell lines HeLa, SK-HEP-1, SW480, and PC-3 is assessed by MTT. The cell viability of HeLa cells is remarkably inhibited by Ginsenoside Rh2, with an IC₅₀ value of 2.52 μg/mL, whereas SK-HEP-1 and SW480 cells are less sensitive to Ginsenoside Rh2, with IC₅₀ values of 3.15 μg/mL and 4.06 μg/mL, respectively. PC-3 cells are the least vulnerable to Ginsenoside Rh2, with an IC₅₀ value of 7.85 μg/mL, 3-fold higher than HeLa cells.

In Vivo: A total of 15 days following B16-F10 cell injection, tumor sizes from the 3 tumor bearing groups are measured. The tumor sizes in the G-L group and G-H group (G-L and G-H refer to a low or high dose of ginsenoside Rh2 injection) are reduced compared with the tumor group (P<0.05). The survival analysis reveals that the Ginsenoside Rh2 treated groups survive longer than the untreated tumor group and the effect is dose-dependent (P<0.05).

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Glycoside Compound Library  |  Lipid Compound Library  |  Medicine Food Homology Compound Library  |  Terpenoids Library  |  Traditional Chinese Medicine Active Compound Library  |  Food-Sourced Compound Library   |  Targeted Diversity Library  |  Anti-Cancer Natural Product Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  Membrane Protein-targeted Compound Library  |  D-Valine-d₈  |  SY-5609  |  D-α-Hydroxyglutaric acid disodium  |  BRD4 Inhibitor-18  |  Nicotinamide N-oxide  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  Deoxycholic acid-d₅  |  Doxorubicin-¹³C,d₃ TFA  |  Palitantin  |  Estradiol hemihydrate  |  AAPK-25  |  Mca-DEVDAP-K(Dnp)-OH  |  Dutasteride-¹³C₆  |  Z-VAD-FMK  |  Adrenaline sulfate  |  Oleic acid-¹³C  |  Dextranase  |  H2S Donor 5a  |  Anticancer agent 120  |  Abacavir sulfate  |  Methylmalonic acid  |  Meloxicam-d₃-1  |  Glycine, N-(aminoiminomethyl)-N-methyl-¹³C  |  Dihydroxyacetone phosphate  |  Thailanstatin D  |  SB-218078  |  Toyocamycin  |  Sorafenib-d₄  |  Sphingomyelin  |  (-)-Jasmonoyl-L-isoleucine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。