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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
37693-01-9
- 规格：
10 mM * 1 mL/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥900.0 |
| 规格： | 500 mg | 产品价格： | ￥2800.0 |
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Clofoctol
CAS No. : 37693-01-9
MCE 国际站：Clofoctol
产品活性：Clofoctol 是一种抗生素, 用于革兰氏阳性菌感染的研究，仅对革兰氏阳性菌起作用, 可渗透入人类肺组织。Clofoctol 也能抑制前列腺癌，具有抗病毒活性。
研究领域：Anti-infection
作用靶点：Bacterial | SARS-CoV | Antibiotic
In Vitro: Clofoctol (0-100 μM; 72 h) inhibits prostate cancer cell growth.
Clofoctol (0-20 μM; 24 h) arrests cell cycle at G1 phase.
Clofoctol (0-30 μM; 0-24 h) induces ER stress and activates UPR pathways.
Clofoctol (0-40 μM; 24 h) inhibits translation.
Clofoctol (0-100 μM; 24 h) shows antiviral effect against SARS-CoV-2 with IC50s of 9.3 μM and 11.59 μM in Vero-81 and Vero-81-TMPRSS2 cells, respectively.
In Vivo: Clofoctol (175 mg/kg; i.p.; daily for 37 days) is capable of blocking tumour growth without apparent toxicity in a mouse model of human prostate cancer xenograft.
Clofoctol (62.5 mg/kg; i.p.; twice) inhibits SARS-CoV-2 replication and lowers inflammation in lungs in mice with SARS-CoV-2 infection.
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