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- 2026年09月08日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
8-Quinolinol
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
148-24-3
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥600.0 |
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8-Hydroxyquinoline
CAS No. : 148-24-3
MCE 国际站：8-Hydroxyquinoline
产品活性：8-Hydroxyquinoline (8-Quinolinol) 是一种亲脂性金属螯合剂，可用作杀菌剂。8-Hydroxyquinoline 对临床分离淋球菌株的最低抑菌范围为 27.56 -55.11 μM (4-8μg/mL)。8-Hydroxyquinoline 可以与铜形成复合物，结合并将铜转运到细胞内。8-Hydroxyquinoline 能够增加小鼠微核多色红细胞的数量，也能使小鼠毛发脱色。
研究领域：Anti-infection
作用靶点：Bacterial | Antibiotic
In Vitro: 8-Hydroxyquinoline (8HQ) (Compd 1) shows cytotoxicity in MRC-5 cells with an IC50 of 6.27 μM.
8-Hydroxyquinoline (8-OHQ) (Compd 1) (mixture of CuCl2 at 10.0 μM, 1 hour) binds to copper and form complexes can facilitate transport of copper into human breast cancer DCIS cells.
8-Hydroxyquinoline (mixture of CuCl2 at 1-20 μM; 1 or 8 hour) binds to copper and form complexes induces cell death with a time and dose-dependent manner in DCIS cells.
8-Hydroxyquinoline (mixture of CuCl2 at 1-5 μM, 2-12 hour) inhibits proteasomal chymotrypsin-like activity.
8-Hydroxyquinoline (0-100 μM, 30 min) acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of C/EBPb DNA-binding activity and NF-jB activation in Raw 264.7 cells.
In Vivo: 8-Hydroxyquinoline (HOQ) (25-100 mg/kg, i.p.,single dose) results in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) in CD1 mice.
8-Hydroxyquinoline (8-HQ) (0.3%, skin administration, 4 times weekly) causes depigmented hair to grow in patterns which change with time in mice.
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文献和实验Deproteination using phenol/chloroform
'Phenol' as used is Analar grade. Phenol should be melted at 65℃,8-hydroxyquinoline added to a final concentration of 0.1%, and equilibrated three times with an equal volume of 1M Tris.HCl, pH 7.0. The final Tris wash is replaced with TE (10
Deproteination using phenol/chloroform
'Phenol' as used is Analar grade. Phenol should be melted at 65℃,8-hydroxyquinoline added
DNA Purification and Precipitation
1.Prepare or obtain Buffered phenol,pH 8.0.Add 2 crystals of 8-Hydroxyquinoline to prevent oxidation.This also identifies the organic phase as yellow-colored. 2.Combine DNA sample with an equal volume of Buffered Phenol. 3.Mix well by vortexing
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