- ¥1 - 3980
- PEPROTECH
- 中国/美国
- xy-578Ra01
- 2026年04月16日
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- 文献和实验
- 技术资料
- 保存条件：
-20℃
- 保质期：
12个月
- 英文名：
Recombinant Pim-1 Oncogene (PIM1)
- 库存：
1000
- 供应商：
上海信裕
| Organism species | Rattus norvegicus (Rat) |
| Product No. | xy578Ra01 |
| Source | Prokaryotic expression |
| Host | E.coli |
| Purity | > 95% |
| UOM | 50ug |
| Predicted Molecular Mass | 17.4kDa |
| Concentration | n/a |
| Applications | SDS-PAGE; WB; ELISA; IP. |
| Endotoxin Level | <1.0EU per 1µg (determined by the LAL method) |
| Formulation | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
MGHHHHHHSGSEF-YQVGPLLGSG GFGSVYSGIR VADNLPVAIK HVEKDRISDW GELPNGTRVP MEVVLLKKVS SGFSGVIRLL DWFERPDSFV LILERPEPVQ DLFDFITERG ALQEELARSF FWQVLEAVRH CHNCGVLHRD IKDENILIDL
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
Pim-1原癌基因(PIM1)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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文献和实验Stem Cell Research & Therapy｜TGF-β1诱导人肾类器官纤维化，PIM1成为候选干预靶点
2026年4月，Stem Cell Research & Therapy 发表研究论文 “Induction of fibrosis in human kidney organoids delineates mechanisms and therapeutic targets of fibrotic kidney disease”。研究团队使用TGF-β1处理人肾类器官，诱导出肾单位结构减少、肌成纤维细胞增加和胶原沉积等纤维化相关改变，并进一步发现PIM1在受损近端小管细胞中升高；使用PIM1抑制
JCI Insight：中山大学苏文如教授团队在眼免疫性疾病的炎症控制和临床靶向防治领域取得新进展
剂治疗反应密切相关的两个经典单核细胞亚群，其特征是：SC2 高表达炎症基因（IL1B 和 IER2），SC4 高表达 JAK-STAT 通路相关基因（PIM1 和 STAT1）。 这些结果系统揭示了 JAKs 抑制剂对免疫系统的作用模式，丰富了 JAKs 抑制剂对单核细胞免疫调节机制的认识，拓宽了 JAKs 抑制剂治疗炎症性疾病的免疫学机制。 图 3 The distributions of two specific CMCs（图源：Liu X, et al., JCI Insight
, GAB2, GNG2, GRB2, HRAS, INDO, KRAS2, KSR, MADH1, MADH2, MADH3, MADH4, MADH5, MADH6, MADH7, MADH9, MAPK8IP1, MCM5, MIZ1, NRAS, OSM, PAK1, PAK3, PIAS1, PIAS3, PIASY, PIM1, PREX1, PTPN1, PTPNS1, PTPRC, RAC1, RAC2, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS
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