- ¥1 - 3980
- PEPROTECH
- 中国/美国
- xy-671Ra01
- 2025年07月16日
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- 文献和实验
- 技术资料
- 保存条件：
-20℃
- 保质期：
12个月
- 英文名：
Recombinant Protein Kinase, AMP Activated Beta 1 (PRKAb1)
- 库存：
1000
- 供应商：
上海信裕
| Organism species | Rattus norvegicus (Rat) |
| Product No. | xy671Ra01 |
| Source | Prokaryotic expression |
| Host | E.coli |
| Purity | > 95% |
| UOM | 50ug |
| Predicted Molecular Mass | n/a |
| Concentration | n/a |
| Applications | SDS-PAGE; WB; ELISA; IP. |
| Endotoxin Level | <1.0EU per 1µg (determined by the LAL method) |
| Formulation | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
AMP激活蛋白激酶β1(PRKAβ1)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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文献和实验Ribonuclease Protection Assay for the Detection of β1-Adrenergic Receptor RNA
epinephrine and norepinephrine; when ligand-activated, these receptors initiate the production of cyclic AMP. Three subtypes of β-ARs, β1 -AR, β2 -AR, and β3 -AR, have been identified on the basis of their pharmacological properties, physiological effects
。抗原激活的T细胞和LPS激活的单核／巨噬细胞分泌具有生物学活性的TGF-β1。TGF-β1的作用显示多功能性，表现为可抑制很多类型细胞的生长，刺激另一些细胞的生长；而且在不同的培养条件下，对于同一类型细胞TGF-β1既能表现抑制作用也能表现刺激作用。TGF-β能刺激胞外基质蛋白(如胶原)、基质蛋白受体(如整合素)和基质修饰酶(如基质金属蛋白酶)的合成。功能上，TGF-β还拮抗淋巴细胞反应，抑制淋巴细胞增殖，抑制CTL成熟，抑制Mφ的激活，抑制促炎症反应性细胞因子的作用，并作为一种信号可关闭免疫
Stem Cell Research & Therapy｜TGF-β1诱导人肾类器官纤维化，PIM1成为候选干预靶点
/STAT信号异常 纤维化类器官中，上皮-间质转化、炎症反应、代谢变化及Janus激酶/信号转导与转录激活因子（JAK/STAT）信号均发生变化。 4. 托法替布可减少TGF-β1诱导的纤维化表型 在TGF-β1处理期间加入JAK/STAT抑制剂托法替布（tofacitinib）后，类器官中STAT3表达下降，α-SMA⁺肌成纤维细胞减少。 5. PIM1抑制剂AZD1208减少促纤维化改变 PIM1在纤维化类器官受损的近端小管细胞中升高；使用AZD1208抑制PIM1后，α-SMA⁺肌成纤维细胞
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