Actinomycin D 放线菌素D Synonym : Actinomycin C1 Actinomycin IV Dactinomycin 放线菌素D 更生霉素 Description: Biochem/physiol Actions:An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Caution:Hygroscopic and light sensitive. 应用范围 抑制RNA的合成,作用于mRNA,干扰细胞的转录过程,阻止蛋白质的合成。临床上主要用于肾母细胞瘤、睾丸肿瘤及横纹肌瘤。对霍奇金氏病、绒毛膜上皮癌、恶性葡萄胎及恶性淋巴瘤亦有一定疗效。 Precautions and Disclaimer: This product is for R&D use only, not for drug,household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices. Product Description: biological source from Streptomyces sp. assay:~98% (HPLC) form:powder color:red, powder red to orange mp:251-253 solubility:DMSO: 1 mg/mL ethanol: soluble storage temp: 2-8°C Ordering Information: