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NTAL/LAB Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2025年10月30日
  • W, IP
  • Rabbit
  • H
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 抗体英文名

      NTAL/LAB Antibody

    • 抗原

      synthetic peptide corresponding to residues surrounding Gly222 of human NTAL/LAB

    • 应用范围

      W, IP

    • 宿主

      Rabbit

    • 级别

      详见MSDS文件

    • 保质期

      详见说明书

    • 供应商

      CST

    • 适应物种

      H

    • 库存

      大量

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W IP H Endogenous 25 Rabbit
    Protocols
    Specificity / Sensitivity

    NTAL/LAB Antibody detects endogenous levels of total NTAL/LAB protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly222 of human NTAL/LAB. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of total cell lysates from SR and SEM cells, using NTAL/LAB Antibody.

    Background

    Non-T cell activation linker (NTAL)/linker for activation of B cells (LAB) is a small transmembrane adaptor protein associated with glycolipid-enriched membrane fractions (1,2). NTAL/LAB is also known as LAT2 (linker for activation of T cells 2), WBSCR5, WBS15, WBSCR15 (Williams-Beuren syndrome chromosome region 15 protein). It is expressed in B cells, monocytes, mast cells, and natural killer cells, but not in resting T cells (3). Upon activation of several receptors, NTAL/LAB becomes tyrosine phosphorylated and recruits signaling molecules such as Grb2 and c-Cbl into receptor-signaling complexes (4-6).

    1. Iwaki, S. et al. (2007) Int J Biochem Cell Biol 39, 868-73.
    2. Lindquist, J.A. et al. (2003) Immunol. Rev. 191, 165-182.
    3. Brdicka, T. et al. (2002) J. Exp. Med. 196, 1617-1626.
    4. Koonpaew, S. et al. (2004) J. Biol. Chem. 279, 11229-11235.
    5. Tkaczyk, C. et al. (2004) Blood 104, 207-214.
    6. Stork, B. et al. (2004) Immunity 21, 681-691.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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    图标文献和实验
    相关实验
    • Antibody Staining of Imaginal Discs

        Antibody Staining of Imaginal Discs From DIS- Thom Kaufman's lab   1. Dissect tissues in Tri-PBS, gather in a 1.5 ml tube of Tri-PBS on ice(at least 10 animals can be processed in one tube).  Tear larvae

    • Generation of Antibody Molecules Through Antibody Engineering

      been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional

    • Protocol for anti-HA antibody Western Blotting

      of interest. 2) Transfer proteins in acrylamide gel to nylon membrane. 3) Block overnight @4℃ in PBS (or TBS, it doesn't matter) with 5% non-fat dry milk. I dilute 2.5 mg in 50 ml. 4) Wash off excess milk sol'n with PBS x3 .(important if you are re-using your antibody

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