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- 详细信息
- 文献和实验
- 技术资料
- 靶点:
For Kit 8209 p70 S6k1 (Thr412) phosphate/p70 S6k1
- 克隆性:
多克隆
- 保存条件:
-20℃
- 规格:
1Kit
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR)-p70(S6K) pathways. The effects of U0126
能结合Akt并通过抑制Akt的磷酸化而阻断下游信号的传递, CTMP的过表达能够逆转v-Akt转化细胞的表型. 热休克蛋白90(HSP90)亦能结合Akt, 阻止Akt被PP2A磷酸酶的去磷酸化而失活, 因此具有保护Akt的作用. 本信号转导涉及的信号分子主要包括 Integrin,FAK,Paxillin,ILK,PIP3,S6,p70S6K,RTK,Gab1,Gab2,IRS-1,PI3K,PTEN,AKT,PDK1,Cytokine Receptor,Jak1,CD19,BCR
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