- 询价
- R&D
- 美国/中国
- xy-585R
- 2025年07月15日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Neurofilament NF-H Monoclonal Antibody保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description 
Monoclonal Antibody against Phosphorylated Neurofilament NF-H Clone NAP4 Form Ascites Host Mouse Species Reactivity Mammalian and Avian IsoType Neurofilament NF-H Monoclonal AntibodyIgG1 Specificity Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Amyothrophic lateral sclerosis (also known as Lou Gehrigs disease) and Alzheimers disease. NAP4 is one of numerous antibodies which reacts preferentially with the axonal phosphorylated forms of NF-H. Interestingly these phosphorylated forms of NF-H are normally restricted to axons, while less phosphorylated forms are found in dendrites. However in numerous damage and disease states, phosphorylated NF-H can be detected with NAP4 in dendritic and perikaryal neurofilaments.
NAP4 was raised against a preparation of native NF-H purified from pig spinal cord. It recognizes phosphorylated NF-H KSP (lysine-serine-proline) type sequences. In some species there is some cross-reactivity with the related phosphorylated KSP sequences found in the related neurofilament subunit NF-M.Uses Neurofilament NF-H Monoclonal AntibodyThis antibody is effective in immunoblotting and immunocytochemistry. This antibody recognizes neurofilaments in frozen sections, cells in tissue culture and in formalin fixed sections. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:10,000*
- Immunofluorescence: 1:1,000
Notes *Predicted MW = 200-220kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. References Harris J, Ayyub C, Shaw G A. Molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J. Neurosci. Res. 30:47-62, 1991. Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Neurofilament NF-H Monoclonal Antibody
- xy-0080xy CD20(抗原)CD20（抗原）
xy-0577xy CD25/IL-2RA(Imterleukm-2 Receptor alpha)CD25/白介素2-受体(抗原)
xy-0468xy CD31(PECAM-1)血小板内皮细胞黏附分子-1（抗原）
xy-0646xy CD34CD34(多肽抗原)
xy-0736xy CD56/NCAM1 (Neural Cell Adhesion Molecule 1)神经细胞粘附分子1(抗原)
xy-0744xy CEAcam8/CD67癌胚抗原相关细胞粘附分子8
xy-1432xy CD68CD68抗原
xy-0672xy CD117/c-kit/SCFR干细胞生长因子受体/细胞表面分化抗原（抗原）
xy-0395xy CD133造血干细胞抗原（多肽抗原）
xy-0684xy CD147/EMMPRIN(Extracellular matrix metalloproteinase inducer)CD147(抗原)
xy-0794xy CD169/sialoadhesin(Sn)(Sialic acid-binding Ig-like lectin 1；Siglec-1)CD169抗原
xy-0624xy CD272/BTLA(B and T lymphocyte attenuator)B 和 T 淋巴细胞衰减蛋白(抗原)
xy-0757xy CDK2 (Cyclin-Dependent Kinase 2)周期素依赖激酶2(抗原)
xy-0633xy CDK4(Cyclin Dependent Kinase 4)周期素依赖性激酶4(抗原)
xy-0060xy CEA人癌胚抗原
xy-0441xy ChRM2 (Muscarinic Acetylcholine receptor M2)毒蕈碱型乙酰胆碱受体M2（抗原）
xy-0651xy Connexin-43(Cx43)间隙连接蛋白43(多肽片断抗原)
xy-0652xy Connexin-45(CX45)间隙连接蛋白45(抗原)
xy-0709xy Anti-Collagen IIII 型胶原(抗原)
xy-1009xy CXCR1 (CXC-chemokine receptor 1)细胞表面趋化因子受体1抗原
xy-0732xy COX-2 (Prostaglandin-endoperoxide synthase-2)前列腺素氧化环化酶2(抗原)
xy-0697xy c-phycocyanin(C-PC)C-藻蓝素(藻蓝蛋白)
xy-0743xy CTGF (connective tissue growth factor)结缔组织生长因子(多肽抗原)
xy-0573xy Cyclin E周期素E/原癌基因抗原
xy-0497xy Dnmt3a(cytosine-5)-methyltransferase 3A)DNA甲基转移酶-3α(抗原)
xy-0282xy Cyclin C周期素 C(抗原)
xy-0791xy CGRP (calcitonin gene related peptide, CGRP)降钙素基因相关肽
xy-0614xy CULLIN (Cdc53/CUL)
xy-0461xy CYP450(Cytochrome P450 monooxygenase)细胞色素P450单氧化酶(多肽抗原)
xy-0488xy CXorf36(uncharacterized protein Cxorf36 precursor)脱羧酶蛋白体36 cxorf36抗原
xy-0399xy Deltex-1(DTX1) (Deltex protein 1)抗原
xy-0428xy DISC1(disrupted in schizophrenia1)(NT)DISC1 N端抗原
xy-0430xy DISC1(disrupted in schizophrenia1)(CT)DISC1 C端抗原
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Neurofilament NF-H Monoclonal Antibody
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