- 询价
- R&D
- 美国/中国
- xy-39730
- 2025年07月13日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- α-Synuclein (4B12) Monoclonal Antibody (SIGNET)保存于运输说明：
- Store at -20°C or below
- 详细信息：
-
Description 
Monoclonal Antibody against Human α-Synuclein
(Formerly Signet Catalog Nos: 9730-02, 9730-05, 9730-10)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 4B12 Form Tissue Culture Supernatant (in PBS; no preservatives or carrier proteins) Host α-Synuclein (4B12) Monoclonal Antibody (SIGNET)Mouse Species Reactivity Human IsoType IgG1 [Ab] 1 mg/mL Specificity α-synuclein is a 140 amino acid protein that is implicated in Parkinson’s disease, Alzheimer’s disease, Lewy body dementia, and multiple system atrophy. Signet’s 4B12 reacts with human α-synuclein. It does not react with mouse or rat α-synuclein.
This antibody was developed using a purified, E. Coli produced human α-synuclein.Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC) and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western/Dot blot: 1:100-1:10,000
- IHC: 1:100-1:1,000
Tissue Sections: Frozen and formalin-fixed paraffin-embedded tissues
Pretreatment: Not required
Storage α-Synuclein (4B12) Monoclonal Antibody (SIGNET)Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puolivali J, Mannisto PT, Garcia-Horsman A, MacDonald E, Beyreuther K, Hartmann T, Jakala P. Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein. Neurobiol Dis 20(2):303-13, 2005. Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - α-Synuclein (4B12) Monoclonal Antibody (SIGNET)
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Proteolytic Fragmentation for Epitope Mapping
Since its introduction in 1975 the methodology of Kohler and Milstein (1 ) for production of monoclonal antibody (MAb) from hybridoma cells has been widely used to provide antibodies with a defined specificity. One characteristic feature
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