- 询价
- R&D
- 美国/中国
- xy-429R
- 2025年07月11日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Human Flightless-I Protein Monoclonal Antibody保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description 
Purified Monoclonal Antibody against Detyrosinated α-Tubulin Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone AA12 Form Purified Antibody (in PBS + 0.03% thimerosal) Host Human Flightless-I Protein Monoclonal Antibody Mouse Species Reactivity Mammalian IsoType IgG2a Specificity Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of α- and β-tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use. This antibody recognizes detyrosinated α-tubulin, a post translational modification of α-tubulin. This antibody was raised against the peptide sequence CGEEEGE and purified on a protein G column. Uses This antibody is effective in immunoblotting and immunofluorescence (IF). Suggested Working Dilution Human Flightless-I Protein Monoclonal Antibody The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:1,000*
- IF: 1:1,000
Notes *Predicted MW = 55 kDa Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM. Reduction of Detyrosinated Microtubules and Golgi Fragmentation Are Linked to Tau-Induced Degeneration in Astrocytes. J Neurosci 23:10662 - 10671, 2003.
Mialhe A, Lafanechere L, Treilleux I, Peloux N, Dumontet C, Bremond A, Panh MH, Payan R, Wehland J, Margolis RL, Job D. Tubulin Detyrosination Is a Frequent Occurrence in Breast Cancers of Poor Prognosis. Cancer Res 61:5024 - 5027, 2001.
Idriss HT. Man to trypanosome: the tubulin tyrosination/detyrosination cycle revisited. Cell Motil Cytoskeleton 45(3):173-84, 2000.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Human Flightless-I Protein Monoclonal Antibody
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文献和实验Human Monoclonal Antibodies: The Residual Challenge of Antibody Immunogenicity
One of the major reasons for seeking human monoclonal antibodies has been to eliminate immunogenicity seen with rodent antibodies. Thus far, there has yet been no approach which absolutely abolishes that risk for cell-binding antibodies
Monoclonal Antibody Production
the antigen you want the MAb directed against.If you are raising the MAbs against a small hapten that you coupled to a carrier protein for immunization of the mice,then use the hapten coupled to a different carrier protein for the screen. 4. Expanding
patterns rather than individual protein markers. The development of an antibody microarray platform of general applicability requires careful consideration of the array content. The human cluster of differentiation (CD) antigens constitute a promising
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