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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
KOE-1173 hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
5370-01-4
- 规格：
10 mM * 1 mL/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥500.0 |
| 规格： | 500 mg | 产品价格： | ￥700.0 |
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Mexiletine hydrochloride
CAS No. : 5370-01-4
MCE 国际站：Mexiletine hydrochloride
产品活性：Mexiletine 是一种口服有效的抗心律失常剂，也被发现对肌强直和神经病理性疼痛有效。Mexiletine 通过阻断钠离子通道 (IC50 : 75±8 μM 于封闭性阻断, 23.6±2.8 μM 于使用依赖性阻断) 发挥作用，可被用于心血管与神经病学研究。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Sodium Channel
In Vitro: Mexiletine (10µM, 48 h) increases peak INa and late INa in HEK293A cells transfected with SCN5A-WT or SCN5A-1795insD while Mexiletine (10µM, 5 min) blocks the late INa.
In Vivo: Mexiletine (30, 100 mg/kg, p.o., acute administration) reverses both mechanical allodynia and cold hyperalgesia in Oxaliplatin (HY-17371) induced rats.
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