Stemolecule™ GSK429286A

Stemolecule™ GSK429286A详细信息：
Product Overview



Stemolecule™ GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK)1. ROCKs are serine/threonine specific protein kinases which play a crucial role in organization of the actin cytoskeleton2. ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2,3. Because of GSK429286A’s specificity, this reagent may be useful in assessing the cellular roles of individual ROCK isoforms.

Stemolecule™ GSK429286AProduct Specifications

Alternate Name N/A
CAS Number N/A
Chemical Formula C21H16F4N4O2
Structure [structure graphics]
Formulation White powder
Stemolecule™ GSK429286AMolecular Weight 432.38
Purity ≥95%
Solubility Soluble to 100mM in DMSO. For a 10 mM concentrated stock solution, reconstitute the compound by adding 463 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage Store lypholized powder at either 4°C or -20°C. Protect from light. Following reconstitution, store aliquots at -20°C.
Stability Stock solutions stable at -20°C for 6 months.
Quality Control The purity of GSK429286A was determined by HPLC analysis. The accurate mass of GSK429286A was determined by mass spectrometry. Cellular toxicity of GSK429286A was tested on mouse embryonic stem cells.
Stemolecule™ GSK429286A
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