Stemolecule™ IPA-3

Stemolecule™ IPA-3详细信息：
Product Overview

Stemolecule™ IPA-3 is an allosteric inhibitor of Pak kinase activation. IPA-3 also inhibits the activation of related Pak kinase isoforms, but not more distantly related Pak kinases or other kinases. IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42. Increasing data implicates Pak1 in tumorigenesis and metastasis, thus suggesting that IPA-3 could be a novel oncologic therapy. Since Pak1 is also implicated as a critical downstream effector of protein kinase C, IPA-3 may prevent differentiation in some tissue development.

Stemolecule™ IPA-3Product Specifications

Size / Quantity 5 mg
Alternate Name 1,1’-Disulfanediyldinaphthalen-2-ol
CAS Number 42521-82-4
Chemical Formula C20H14O2S2
Structure [structure graphics]
Formulation Off white to yellow powder
Molecular Weight 350.45
Stemolecule™ IPA-3Purity ≥98%
Solubility Soluble to 75mM in DMSO. For a 10 mM concentrated stock solution, reconstitute the compound by adding 1427 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20C.
Stability Stock solutions stable at -20°C for 6 months.
Quality Control The purity of IPA-3 was determined by HPLC analysis. The accurate mass of IPA-3 was determined by mass spectrometry. Cellular toxicity of IPA-3 was tested on mouse embryonic stem cells.
Notice to Purchaser Purchaser represents and warrants that it will use Stemolecule™ IPA-3 purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products.
Stemolecule™ IPA-3
xy10021 砖红链霉菌
xy10022 猪肾细胞系 PK15细胞
xy10023 猪肾细胞系 PK13细胞
xy10024 猪肾细胞系 IBRS-2细胞
xy10025 猪肾细胞,PK-15细胞,
xy10026 猪肾细胞,LLC-PK1细胞
xy10027 猪肾上皮细胞,PK15-EGFP-puro细胞
xy10028 猪肾上皮细胞,PK（15）细胞
xy10029 猪肾近曲小管上皮细胞,LLC-PK1细胞
xy10030 猪髋动脉内皮细胞,PIEC细胞,
xy10031 猪霍乱沙门氏菌猪霍乱亚种
xy10032 猪骨髓间质干细胞,Pig MSC细胞
xy10033 猪睾丸细胞系 ST细胞
xy10034 猪肺泡巨噬细胞,3D4/21细胞
xy10035 猪鼻甲黏膜成纤维细胞,PT-K75细胞
xy10036 皱褶青霉
xy10037 中华根霉
xy10038 中国仓鼠体细胞,R 1610(细胞
xy10039 中国仓鼠肾细胞(二氢叶酸还原酶缺陷型) CHO/dhFr-细胞
xy10040 中国仓鼠卵巢细胞,CTLA4 Ig-24细胞
xy10041 中国仓鼠卵巢细胞,CHO细胞,
xy10042 中国仓鼠肺细胞,V79细胞
xy10043 中国仓鼠肺细胞,V79-4细胞
xy10044 中国仓鼠肺细胞,CHL细胞
xy10045 中国仓鼠肺细胞,CHL/IU [ CHL-11 ]细胞
xy10046 中国仓鼠二氢叶酸还原酶缺陷细胞,CHO/dhFr-细胞
xy10047 中国仓鼠仓鼠卵巢细胞亚株 CHO-K1细胞
xy10048 中国仓鼠仓鼠肺细胞,R1610细胞
xy10049 中国仓鼠X小鼠B淋巴细胞杂交瘤 MR1细胞,
xy10050 致病性大肠埃希氏菌
xy10051 植物乳杆菌
xy10052 正常小鼠睾丸Sertoli细胞,TM4细胞
xy10053 正常小鼠睾丸Leydig细胞,TM3细胞
xy10054 正常人肝细胞,L-02细胞
xy10055 正常大鼠肾细胞,NRK细胞
xy10056 整合SV40 基因的乳腺上皮细胞,HBL-100?细胞
xy10057 赭曲霉
xy10058 赭绿青霉
xy10059 沼泽红假单胞菌
xy10060 张氏肝细胞,HeLa [ Chang Liver ]细胞
xy10061 粘质沙雷氏菌
xy10062 粘质沙雷伯氏菌
xy10063 粘红酵母
xy10064 早代小鼠胚胎成纤维细胞,MEF细胞