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- xy-0032
- 2025年07月10日
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- 详细信息
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule™ SHH Antagonist
- 库存：
1
- 供应商：
上海信裕
- Stemolecule™ SHH Antagonist详细信息：
-
Product Overview
Stemolecule™ SHH Antagonist is an inhibitor of Sonic hedgehog signaling (SHH)1. Hedgehog signaling plays key roles in a wide variety of development process2 as well as cancer progression3. The vertebrate family of hedgehog genes that have been identified are known as Sonic (Shh), Desert (Dhh), and Indian (Ihh) hedgehogs, all of which encode secreted proteins. Among the three, Sonic hedgehog (SHH) is the best studied ligand of the vertebrate pathway. One of the best studied examples is the action of Sonic hedgehog during development of the vertebrate limb, in which both the concentration and the time of exposure to SHH determines which digit into which the tissue will develop4. Stemolecule™ SHH Antagonist is the result of a compound screening for inhibiting activation of the hedgehog signaling pathway, e.g. inhibition of aberrant growth states resulting from phenotypes such as hedgehog gain-of-function1.
Stemolecule™ SHH AntagonistProduct Specifications
Size / Quantity 2 mg Lot Number 1195 Alternate Name N-(4-ethoxyphenyl)-4-(2-methylimidazol[1,2-a]pyridine-3-yl)thiazol-2-amine, 2-amino-thiazole, Sonic hedgehog antagonist CAS Number N/A Chemical Formula C19H18N4OS Structure Formulation Stemolecule™ SHH Antagonist light pink color Molecular Weight 350.44 Purity >99% Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 571 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20oC. Stability Stock solutions stable at -20°C for 6 months. Quality Control The purity of SHH Antagonist was determined by HPLC analysis. The accurate mass and structure of SHH Antagonist were determined by mass spectrometry and NMR, respectively. Cellular toxicity of SHH Antagonist was tested on mouse ES cells. Related Products Stemolecule™ SMO Antagonist (Cat. # 04-0031) Notice to Purchaser Purchaser represents and warrants that it will use Stemolecule™ SHH Antagonist purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products. - Stemolecule™ SHH Antagonist
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