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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
4℃保存
- 保质期:
6个月
- 英文名:
Stemolecule Sodium Butyrate
- 库存:
1
- 供应商:
上海信裕
- Stemolecule Sodium Butyrate保存于运输说明:
- 4°C protected from light. Following reconstitution, store aliquots at -20°C
- 详细信息:
-
Stemolecule™ Sodium Butyrate
Sodium butyrate is the sodium salt of the short-chain fatty acid butyric acid1. Butyrate is a metabolite of intestinal bacteria and a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract2. The effects of sodium butyrate on cell volume regulation and chloride transport in the rat distal colon were first described by M. Diener et al. in 19973. Sodium butyrate is a known inhibitor of histone deacetylases4,5. The enhancement and suppression of various cytokines in stimulated human monocytes using sodium butyrate was first reported in 20002. In cultured mouse and human cells, sodium butyrate has been shown to inhibit both the mRNA and protein level of cyclin D16. View Poster
Stemolecule Sodium Butyrate产品参数
Chemical Formula C4H7NaO2 Structure Molecular Weight 111.1 CAS Number 156-54-7 PubChem Substance ID 24891873 Purity >98% by titration Formulation Stemolecule Sodium Butyrate White solid Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 4500 µl of DMSO to 5 mg of compound. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage 4°C protected from light. Following reconstitution, store aliquots at -20°C Stability Stock solutions stable at -20°C for 6 months Quality Control The purity of sodium butyrate was determined by HPLC analysis. The accurate mass and structure of sodium butyrate was determined by mass spectrometry and NMR, respectively. Cellular toxicity of sodium butyrate was tested by using HeLa and HEK293 cells. References - Kolthoff, I. M. et al., Quantitative Chemical Analysis, 4th ed., MacMillan Pub. (New York, NY: 1969).
- Saemann, M. D. et al., FASEB J., 14(15):2380-2382 (2000).
- Diener, M., and Scharrer, E., Biochem. Physiol. A Physiol., 118(2):375-379 (1997).
- Kruh, J., Mol. Cell. Biochem. ,42(2):65-82 (1982).
- Ware C.B., Wang L., Mecham B.H., Shen L., Nelson A.M., Bar M., Lamba D.A., Dauphin D.S., Buckingham B., Askari B., Lim R., Tewari M., Gartler S.M., Issa J.P., Pavlidis P., Duan Z., Blau C.A. (2009) Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell 4(4):359-69.
- Lallemand, F. et al., Biochem. Biophys. Res. Commun., 229(1):163-169 (1996).
- Stemolecule Sodium Butyrate
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xy-0605xy IL-2 (Interleukin-2)HumanIL-2抗原(人)
xy-1193xy IL-23(Interleukin-23)白介素-23抗原
xy-0581xy IL-4(Interleukin-4)白介素4抗原
xy-1740xy IL-4(Interleukin-4)human peptide白介素4抗原
xy-1318xy IL-5 peptide白细胞介素5抗原
xy-0781xy IL-6 (Interleukin-6) Human白介素6
xy-1811xy IL-7(Interleukin-7)白介素7抗原
xy-1805xy IL-6R Alpha (IL6R-alpha)白细胞介素6受体α抗原
xy-1459xy gp130/IL-6R白介素-6受体抗原
xy-1540xy IL-7Ra/CD127 peptide白细胞介素-7受体a抗原
xy-1291xy ING1/p33(inhibitor of growth gene 1)生长抑制因子基因1抗原
xy-1032xy Inhibin Alpha抑制素α抗原
xy-1774xy Inhibin beta A peptide抑制素beta A抗原
xy-1825xy Inhibin beta B抑制素βB抗原
xy-2093xy Integrin Alpha3整合素α3抗原
xy-2094xy Integrin Beta5整合素β5抗原
xy-2095xy Integrin alpha 1整合素α1抗原
xy-1051xy Integrin Alpha4 Beta7/LPAM-1 (Lymphocyte Peyer’s patch Adhesion Molecule 1/Integrin alpha4,beta7)整合素α4β7抗原
xy-1274xy Integrin AlphaE2/CD103整合素αE2抗原
xy-1568xy ENPP3/CD203c(ectonucleotide pyrophosphatase/phosphodiesterase 3)ENPP3抗原
xy-1109xy IQGAP1支架蛋白抗原
xy-1404xy IRF-1(Interferon regulatory factor-1)干扰素调节因子抗原
xy-1427xy IRAK 2白介素-1受体相关激酶2
xy-2216xy IL-1RA (Interleukin-1 receptor antagonist)peptide白介素-1受体拮抗剂抗原
xy-1816xy Integrin a7(integrin alpha 7)整合素α7抗原
xy-0486xy integrin Beta1(ITG- Beta1/CD29)粘附分子整合素β1抗原
xy-0567xy Integrin Alpha5(ITG- AlphaV/CD49e)粘附分子整合素α5抗原
xy-2250xy Integrin alpha V/CD51 peptide整合素αV抗原
xy-1439xy JAK1(Tyrosine-protein kinase JAK1; Janus kinase 1)蛋白质酪氨酸激酶JAK-1抗原
xy-0908xy JAK2(Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2)蛋白质酪氨酸激酶JAK-2抗原
xy-2485xy phospho JAK2(phospho-Tyr1007+Tyr1008)磷酸化蛋白酪氨酸激酶JAK-2抗原
xy-0501xy JNK1/3 (c-Jun amino-terminal kinase 1/3)c-Jun氨基末端激酶1/3多肽抗原
xy-1640xy phospho-JNK1/2/3(pThr183/pTyr185) peptide磷酸化氨基末端激酶1/2/3(pJNK1/2/3)抗原
xy-2130xy Ki-67(Antigen identified by monoclonal antibody Ki 67)Ki-67 Antigen
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文献和实验Two hypothetical concepts are discussed as means to cure cancer: 1) extinction of the neoplastic cell pool which forms the tumor and 2) induction of terminal differentiation to park tumor cells in growth arrest (1 ). Sodium butyrate (NaB
Identification and Characterization of Herpesviral Immediate-Early Genes
by their transcription following primary infection or reactivation in the presence of inhibitors of protein synthesis. This chapter describes an approach to identify IE genes in a novel herpesvirus genome. Transcription of IE genes is selectively induced with sodium
Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines
(5 ) and hexamethylene bisacetamide (6 ), fatty acid salts (for example, sodium butyrate (7 ), retinoic acid and some of its derivatives (8 ) (for a comprehensive list of inducers, see ref. 9 ).
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