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        Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines

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        Murine erythroleukemia (MEL) cell lines are erythroid progenitor cells derived from the spleens of susceptible mice infected with the Friend virus complex 1 . These virally transformed cells are arrested at the proerythroblast stage of development and can be maintained in tissue culture indefinitely (2 ). Most MEL cell lines show a low (approx 1 %) level of spontaneous erythroid differentiation, which is dependent on the culture conditions as well as the cell line in question (2 4 ). However, upon treatment with various chemical agents, MEL cells can be induced to undergo erythroid differentia- tion at much higher levels (30–100%). Among the most potent inducers of differentiation are polar-planar compounds (such as dimethyl sulfoxide (5 ) and hexamethylene bisacetamide (6 ), fatty acid salts (for example, sodium butyrate (7 ), retinoic acid and some of its derivatives (8 ) (for a comprehensive list of inducers, see ref. 9 ).
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