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Stemolecule SC1 (Pluripotin)

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  • 询价
  • ATCC
  • 美国/中国
  • xy-04-0011
  • 2025年07月15日
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    上海信裕生物科技有限公司
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件：

      4℃保存

    • 保质期：

      6个月

    • 英文名：

      Stemolecule SC1 (Pluripotin)

    • 库存：

      1

    • 供应商：

      上海信裕

    • Stemolecule SC1 (Pluripotin)保存于运输说明：
    • 4°C protected from light. Reconstitute by using DMSO to make 100 mM. Following reconstitution, store aliquots at -20°C.
    • 详细信息：

    • Stemolecule™ SC1 (Pluripotin)

      SC1 (Pluripotin) was identified in a cell-based screen of a chemical library for small molecules that regulate the mouse embryonic stem (ES) cell self-renewal1. It was shown that SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Inactivation of ERK1 blocks differentiation, whereas inhibition of Ras-GAP activates Ras and PI3K, promoting self-renewal of mouse ES cells. Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo.
      在不含LIF,饲养层细胞或血清的非分化条件下长时间的有效维持小鼠胚胎干细胞的自我更新，可代替LIF维持小鼠胚胎干细胞的自我更新。用SC1培养的细胞在传代5代之后能维持多能marker的表达（Oct4,Sox2,Nanog,SSEA1），双重抑制extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP)，经验证其浓度在1uM以下无细胞毒性。

      Stemolecule SC1 (Pluripotin)产品参数

      Chemical Formula C27H25F3N8O2
      Alternate Name Pluripotin
      Structure
      Molecular Weight 550.54
      Purity >98.5%
      Formulation Stemolecule SC1 (Pluripotin) White solid
      Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 624 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
      Storage 4°C protected from light. Reconstitute by using DMSO to make 100 mM. Following reconstitution, store aliquots at -20°C.
      Stability Stock solutions stable at -20°C for 6 months
      Quality Control The purity of SC1 was determined by HPLC analysis. The accurate mass and structure of SC1 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of SC1 was tested on mouse ES cells, HeLa and HEK293 cells.
      References
      1. Chen, S., Do, J. T., Zhang, Q., Yao, S., Yan, F., Peters, E. C., Schöler, H. R., Schultz, P. G., and Ding, S. (2006) Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci USA 103(46):17266-17271.
      Stemolecule SC1 (Pluripotin)
    • xy-0549xy Collagen III (Anti-Collagen Type III )抗Ⅲ型胶原抗原(Collagen Ⅲ Ⅲ型胶原)
      xy-0948xy Collagen III (Anti--Collagen Type III )Ⅲ型胶原抗原(Collagen Ⅲ Ⅲ型胶原)
      xy-0806xy Collagen IVIV型胶原(Collagen Ⅳ Ⅳ 型胶原)
      xy-0578xy Collagen I(Anti-Collagen Type I)I型胶原蛋白
      xy-0552xy Collagen V (Anti--Collagen Type V )Ⅴ型胶原(多肽)
      xy-1428xy CLDN1(Claudin 1)紧密连接蛋白1抗原
      xy-2183xy Claudin-11 peptide少突胶质细胞跨膜蛋白抗原
      xy-0790xy CLDN1(Claudin 1)C-term紧密连接蛋白1抗原(C端)
      xy-0582xy COX-1 (Prostaglandin-endoperoxide synthase-1)前列腺素氧化环化酶1抗原
      xy-2047xy CPT1A peptide肉毒碱棕榈酰基转移酶1A多肽抗原
      xy-1790xy CRMP2/Dpysl2(collapsin response mediator protein-2)二氢嘧啶酶样2CRMP2抗原
      xy-1860xy CRLR/CALCRL(calcitonin receptor like precursor)降钙素受体样蛋白抗原
      xy-1703xy cRaf/Raf1(c-raf 1)cRaf/Raf1抗原
      xy-1433xy MEK1/MAPKK1(mitogen activated protein kinase kinase 1)MEK1/MAPKK1抗体(N-端)
      xy-0382xy CRF (Corticotropin-Releasing Factor)促肾上腺皮质激素释放因子
      xy-0793xy CSIG(cellular senescence inhibited gene)细胞衰老抑制基因抗原
      xy-0848xy Anti-CSP (circumsporozoite protein/Plasmodium yoelii)环子孢子蛋白(约氏疟原虫)抗原
      xy-2174xy Calcitonin降钙素抗原
      xy-1410xy CTBP1(C-terminal binding protein 1)C端结合蛋白1抗原
      xy-1179xy CTLA-4/CD152淋巴细胞相关抗原4/细胞毒性T细胞抗原-4
      xy-0799xy CTn1 (cardiac troponin 1)心肌肌钙蛋白
      xy-1376xy Cx32(Connexin-32)间隙连接蛋白32抗原
      xy-1266xy CX36 (Connexin-36)间隙连接蛋白36抗原
      xy-1050xy Cx40 (Connexin-40)间隙连接蛋白40(多肽)
      xy-0811xy cx3cl1(chemokine (C-X3-C motif) ligand 1)趋化因子(C-X3-C 基元)配体1抗原
      xy-1728xy CX3CR1(CX3C-chemokine receptor 1)CX3C趋化因子受体1抗原
      xy-0571xy Cyclin A周期素A抗原
      xy-0572xy Cyclin B1周期素B1抗原
      xy-1148xy Cyclin D2周期素D2抗原
      xy-0660xy Cyclin D3(C-term)周期素D3抗原
      xy-1742xy CYP3A4(Cytochrome p450 3A4)细胞色素P450 3A4抗原
      xy-1290xy Cyr61/IGFBP10/CCN1(cysteine rich 61)富半胱氨酸肝素结合蛋白61抗原
      xy-0896xy HCMV UL23/HHV5 UL23(Human Cytomegalovirus UL23 Gene)人巨细胞病毒UL23抗原
      xy-1007xy DAD1 (dopamine D1 receptor)多巴胺受体-D1抗原
      Stemolecule SC1 (Pluripotin)xy-1743xy DRD3 receptor(dopamine D3 receptor)多巴胺受体-D3抗原
      xy-1746xy DRD4 receptor peptide多巴胺受体-D4抗原

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    图标文献和实验
    相关实验

    • 无白血病抑制因子条件下利用SC1（pluripotin）维持小鼠胚胎干细胞的自我更新

      小鼠胚胎干细胞常规培养时需要用到白血病抑制因子（LIF），但是LIF非常昂贵。本视频将展示一种很实惠的替代方法，即以小分子SC1代替LIF维持小鼠胚胎干细胞自我更新。 0:00 无白血病抑制因子条件下利用SC1（pluripotin）维持小鼠胚胎干细胞的自我更新 0:08 内容简介 0:51 维持小鼠胚胎干细胞的自我更新 3:11 免疫细胞化学法检测多潜能标记 4:54 SC1存在条件下小鼠干细胞生长的代表性图像结果 5:28 结论 无白血病抑制因子条件下利用SC1

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