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- 2025年12月26日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Asn53-Ser177
- 保质期：
See instructions
- 英文名：
标签:C-Fc
- 库存：
表达系统:Human Cells
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥760.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2000.0 |
| 规格： | 500ug | 产品价格： | ￥12320.0 |
| 规格： | 1mg | 产品价格： | ￥17600.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.
Biochemical Analysis of the Native TRAIL Death-Inducing Signaling Complex
receptor 1 (TRAIL-R1/DR4), TRAIL-R2 (KILLER/APO-2/DR5/TRICK), CD95 (Fas, APO-1), or TNF receptor 1 (TNF-R1), this complex is termed death-inducing signaling complex (DISC). The compositions of the various DISCs have been intensively studied in the last 12
／Apol(23％同源)的同源序列。TRAIL／Ap02L属于Ⅱ型膜蛋白，但可以被水解后释放，存在于各种组织中。TRAIL有两个细胞膜受体：TRAIL-R1(DR4)和TRAIL-R2(DR5)。这两个受体都有细胞内的死亡结构域，可以传递凋亡信号。此外，还有两个缺陷受体(decoyreceptor)：DcRl和DcR2，也被称之为TRAIL-R3和TRAIL-R4。 尽管Ap02／TRAIL的生物活性与诱导凋亡有关，但其确切的生理功能并不十分清楚。小鼠Ap02L／TRAIL基因敲除模型显示
Combined Fertility and Embryotoxicity Study
Under normal circumstances, fertility and embryotoxicity studies are run separately according to the ICH S5(R2) guideline for the detection of toxicity to reproduction of medicinal products (1). However, the flexible approach of the S5(R2
技术资料