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- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Asn53-Ser177
- 保质期：
See instructions
- 英文名：
标签:C-Fc
- 库存：
表达系统:Human Cells
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥760.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2000.0 |
| 规格： | 500ug | 产品价格： | ￥12320.0 |
| 规格： | 1mg | 产品价格： | ￥17600.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.
Biochemical Analysis of the Native TRAIL Death-Inducing Signaling Complex
receptor 1 (TRAIL-R1/DR4), TRAIL-R2 (KILLER/APO-2/DR5/TRICK), CD95 (Fas, APO-1), or TNF receptor 1 (TNF-R1), this complex is termed death-inducing signaling complex (DISC). The compositions of the various DISCs have been intensively studied in the last 12
／Apol(23％同源)的同源序列。TRAIL／Ap02L属于Ⅱ型膜蛋白，但可以被水解后释放，存在于各种组织中。TRAIL有两个细胞膜受体：TRAIL-R1(DR4)和TRAIL-R2(DR5)。这两个受体都有细胞内的死亡结构域，可以传递凋亡信号。此外，还有两个缺陷受体(decoyreceptor)：DcRl和DcR2，也被称之为TRAIL-R3和TRAIL-R4。 尽管Ap02／TRAIL的生物活性与诱导凋亡有关，但其确切的生理功能并不十分清楚。小鼠Ap02L／TRAIL基因敲除模型显示
-1R1 Mammalian Cells 85-110 kDa Pr22492 Recombinant Mouse IL-1R1 Mammalian Cells 50-90 kDa P4967 Recombinant Mouse IL-1RA E.Coli 19.2 kDa Pr22606 Recombinant Mouse IL-1R2 Mammalian Cells 45-60 kDa Pr
技术资料
