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Human Siglec-5(C317)

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  • ¥588 - 12320
  • SinoBio
  • 国产
  • C317
  • 2026年08月15日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      蛋白表达区间:Glu17-Thr434

    • 保质期

      See instructions

    • 英文名

      标签:C-6His-Flag-Fc

    • 库存

      表达系统:Human Cells

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥588.0
    规格:50ug产品价格:¥1764.0
    规格:500ug产品价格:¥8624.0
    规格:1mg产品价格:¥12320.0
    产品描述
    Recombinant Human Sialic Acid-binding Ig-like Lectin 5 is produced by our Mammalian expression system and the target gene encoding Glu17-Thr434 is expressed with a 6His, Flag, human IgG1 Fc tag at the C-terminus.
    蛋白编号
    O15389
    产品别称
    Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170
    偶联
    Unconjugated
    分子量
    74.1 KDa
    表观分子量
    90-110 KDa, reducing conditions
    剂型描述
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    复溶
    • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
    • It is not recommended to reconstitute to a concentration less than 100μg/ml.
    • Dissolve the lyophilized protein in distilled water.
    • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
    运输条件
    • The product is shipped at ambient temperature.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
    • Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
    • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    产品背景
    Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily,They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type domains. SIGLEC5 has also been designated CD170, they are expressed by monocytic or myeloid lineage cells, and also found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. SIGLEC5 are expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. One remarkable feature of the CD33 related Siglecs is their differential expression pattern within the hematopoietic system This fact, together with the presence of two conserved immunoreceptor tyrosinebased inhibition motifs (ITIMs) in their cytoplasma tails, suggests that CD33 related Siglecs are involved in the regulation of cellular activation within the immune system.

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    图标文献和实验
    该产品被引用文献

    Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily,They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type domains. SIGLEC5 has also been designated CD170, they are expressed by monocytic or myeloid lineage cells, and also found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. SIGLEC5 are expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. One remarkable feature of the CD33 related Siglecs is their differential expression pattern within the hematopoietic system This fact, together with the presence of two conserved immunoreceptor tyrosinebased inhibition motifs (ITIMs) in their cytoplasma tails, suggests that CD33 related Siglecs are involved in the regulation of cellular activation within the immune system.

    相关实验
    • Modification of Alginate Using Mannuronan C-5-Epimerases

      , however, epimerization reactions take place after the polysaccharides are formed. This type of postpolymerization epimerization is a feature of several uronic-acid containing polysaccharides found both in eukaryotes and in bacteria. These reactions are exemplified by C-5

    • Mutational Analysis of the Human Protein C Gene

      The single gene for protein C is located at position q13–q14 on chromosome 2 (1 ). Two groups have described human genomic clones of protein C isolated from phage l charon libraries using cDNA for human protein C as hybridization probes

    • 解码Siglec家族:关键成员、作用机制与实验研究策略

      169)、Siglec-2(CD22)、Siglec-4(MAG)、Siglec-15   这类成员在物种间高度同源,承担基础性生理功能。例如,Siglec-1 凭借多达 16 个 C2-set 结构域,可在巨噬细胞表面实现长距离抗原捕获;Siglec-15 则因结构与 PD-L1 相似,且在肿瘤免疫中具备独特的双向调节潜力而备受关注。 CD33 相关型(CD33-related Siglecs) 成员包括:Siglec-3(CD33)、Siglec-5Siglec-6、Siglec

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    文献支持
    Human Siglec-5(C317)
    ¥588 - 12320