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- 2026年08月13日
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- 文献和实验
- 技术资料
- 保质期：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 保存条件：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 英文名：
Siglec-5
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥764.00 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥2293.00 |
| 规格： | 500ug | 产品价格： | ¥10349.00 |
| 规格： | 1mg | 产品价格： | ¥14784.00 |
| 基因名 | Siglec-5 |
| 别名 | Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170 |
| 蛋白号 | O15389 |
| 种属 | Human |
| 宿主 | HEK293 |
| 产品描述 | Recombinant Human Sialic Acid-binding Ig-like Lectin 5 is produced by our Mammalian expression system and the target gene encoding Glu17-Thr434 is expressed with a 6His, Flag, human IgG1 Fc tag at the C-terminus. |
| 区间范围 | Glu17-Thr434 |
| 标签信息 | C-6His-Flag-Fc |
| 预测分子量 | 90-110 kDa |
| 表观分子量 | 90-110 KDa, reducing conditions |
| 纯度 | ≥95% by SDS‐PAGE. |
| 内毒素 | <1EU/ug as determined by LAL test. |
| 溶剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Histidine, 10% Trehalose, 2% Mannitol, 50mM NaCl, 0.05% Tween80, pH 5.5. |
| 复溶 | Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: 2-8°C for 2-7 days under sterile conditions after redissolves; -20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; -20°C to -70℃ for 12 months in lyophilized state. |
| 运输条件 | 冷冻运输 |
| 背景说明 | Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily, They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type domains. SIGLEC5 has also been designated CD170, they are expressed by monocytic or myeloid lineage cells, and also found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. SIGLEC5 are expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. One remarkable feature of the CD33 related Siglecs is their differential expression pattern within the hematopoietic system This fact, together with the presence of two conserved immunoreceptor tyrosinebased inhibition motifs (ITIMs) in their cytoplasma tails, suggests that CD33 related Siglecs are involved in the regulation of cellular activation within the immune system. |
| 细胞活性 | No activity experimental data, to be verified. |
| ELISA活性 | No activity experimental data, to be verified. |
| SPR/BLI活性 | No activity experimental data, to be verified. |
| 研究领域 | 生物制药相关研究 |
| 英文名称 | Siglec-5 |
| 中文名称 | Siglec-5蛋白 |
| 单位 | 支 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
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169）、Siglec-2（CD22）、Siglec-4（MAG）、Siglec-15 这类成员在物种间高度同源，承担基础性生理功能。例如，Siglec-1 凭借多达 16 个 C2-set 结构域，可在巨噬细胞表面实现长距离抗原捕获；Siglec-15 则因结构与 PD-L1 相似，且在肿瘤免疫中具备独特的双向调节潜力而备受关注。 CD33 相关型（CD33-related Siglecs） 成员包括：Siglec-3（CD33）、Siglec-5、Siglec-6、Siglec
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