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上海善然生物科技有限公司
Application
Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples.1 It was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas.2
Biochem/physiol Actions
Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3.3,4 Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.5
性质
Related Categories Antibacterial, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecule Alphabetical Index, Chemical Structure Class,
Interferes with Cell Membrane Permeability (Ionophores), Ion Channels, Ionophores, L - Z, Mechanism of Action, Monovalent Ion Channels, Polyethers, S, Spectrum of Activity, Voltage-gated Ion Channels, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
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biological source from Streptomyces albus
assay ≥98% (HPLC)
mp 112.5-113.5 °C(lit.)
storage temp. 2-8°C
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文献和实验S－腺苷甲硫氨酸 S－ adenosylmethionine 亦称活性甲硫氨酸，在生物体内由 ATP与甲硫氨酸在甲硫氨酸活化酶的作用下合成。甲硫键是高能键，另外其丙基胺部分也加入到多胺化合物中。当胆碱、肌酸及其它甲基化合物生成时它作为甲基供体而起作用。认为甲硫氨酸的分解也经过此物质。
Summary: Illumina's Solexa Sequencing Technology
Here I present a brief overview of Solexa's sequencing-by-synthesis chemistry. The sample prep methods used differ slightly from that used in ABI's SOLiD system, but the basic goals are the same: generate large numbers of unique "polonies
鹅〔脱氧〕胆酸 s chenodeoxycholic acid
C 24 H 40 O 4 。 3 α， 7 α - 二羟基 -5 β - 胆烷酸。胆汁酸的一种。在哺乳类、鸟类、鱼类等的胆液中含有和甘氨酸或牛磺酸结合形成的甘氨鹅（脱氧）胆酸或牛磺鹅（脱氧）胆酸。
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