- ￥3000 - 3999
- Abbiotec
- 美国
- 250600
- 2025年07月16日
- E, WB, IHC
- Rabbit
- H
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human c-erbB2.
- 亚型：
Rabbit Ig
- 形态：
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆抗体
- 标记物：
见下方详细说明
- 适应物种：
H
- 宿主：
Rabbit
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
c-erbB-2
- 抗体英文名：
c-erbB-2 Antibody
- 抗体名：
c-erbB-2 Antibody
- 规格：
0.1 mg
c-erbB-2 Antibody产品详细介绍：
| 产品名称： | c-erbB-2 Antibody |
| 说明书： | http://www.abbiotec.com/antibodies/c-erbb-2-antibody【参考图片】 |
| 货号： | 250600 |
| 规格： | 0.1 mg |
| 产品描述： | C-erbB-2 (HER2) is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. HER2 has no ligand binding domain on its own and therefore cannot bind growth factors. However, HER2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human c-erbB2. |
| 适用物种： | H |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
| 别名： | Receptor tyrosine protein kinase erbB2; p185erbB2; C-erbB-2; Neu proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; ERBB2; HER2; NEU; NGL |
| 形态： | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验both at transcriptional or posttranscriptional levels (8 -10 ). Recombinant fusion proteins consisting of various bacterial toxins selectively targeted to the tumor by virtue of single-chain anti-erbB- 2 antibody (sFv) moieties has also been utilized in this context (7 ).
c-erbB 编码 EGF 受体，是一种分子量为 65KDa 的跨膜蛋白，由 1186 个氨基酸组成。膜外的部分（ 621aa ）是 EGF 结合功能区。前面有 24aa 构成的信号肽。跨膜区由 23 个疏水氨基酸组成。膜内部分由 542aa 组成。其中包括 4 个磷酸化位点和一个 TPK 功能区。 4 个磷酸化位点中有一个是紧靠膜内侧的 654 位 Thr ，其余 3 个位于 1068 ， 1148 和 1173Tyr 自身磷酸化位点
c-erbB-2 Immunohistochemistry in Paraffin Tumors
Immunohistochemistry is the study of the intracellular distribution of antigens based on the formation of an immune complex. The concept is based on the application of a specific antibody to the antigen to be detected and visualization
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