Makorin Ring Finger Protein 1

yb310435 产品详细信息
Makorin Ring Finger Protein 1 (MKRN1) (N-Term) 抗体
anti-Makorin Ring Finger Protein 1 (MKRN1) (N-Term) antibody anti-Makorin Ring Finger Protein 1 (MKRN1) (N-Term) antibody (2)
抗原
Makorin Ring Finger Protein 1 (MKRN1)
别名 MKRN1, MGC84269, mkrn1, Makorin-1, RNF61, RFP
抗原表位
其他选择 N-Term
适用
其他选择 小鼠, 大鼠, 犬, 牛, 人, 小鸡
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
应用范围
其他选择 Western Blotting (WB)
Pubmed 找到1个引用
规格 100 μg
发货至 中国 (更改)
发货时间 9至12个工作日
产品细节Makorin Ring Finger Protein 1 (MKRN1) (N-Term) 抗体
免疫原 Synthetic peptide directed towards the N terminal of human MKRN1
序列 GDRCRYEHSK PLKQEEATAT ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE
预测反应 Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Chicken : 80 %, Guinea pig : 70 %, African clawed frog : 70 %, Zebrafish : 70 %
产品特性 This is a rabbit polyclonal antibody against MKRN1. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Protein A purified
目标详细情况 Makorin Ring Finger Protein 1 (MKRN1) (N-Term) 抗体
别名 MKRN1
背景 The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
分子量 16 kDa
基因ID 23608
NCBI登录号 NP_038474, NM_003338
UniProt Q9UHC7
研究领域 Proteolysis / Ubiquitin, Transcription Factors
使用细节 Makorin Ring Finger Protein 1 (MKRN1) (N-Term) 抗体
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明
Antigen size: 147 AA
限制 仅限研究用
贮存及处理 Makorin Ring Finger Protein 1 (MKRN1) (N-Term) 抗体
状态 Lyophilized
溶解方式 Add 100 µL of distilled water.
浓度 1 mg/mL
缓冲液 PBS buffer with 2 % sucrose
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For longer periods of storage, store at -20 °C
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