PI3KC3 (pSer282) 抗体

PI3KC3 (pSer282) 抗体抗原
PI3KC3
抗原表位
其他选择 pSer282
适用
其他选择 人
宿主
其他选择 兔
克隆类型 (克隆位点)
多克隆 (RB11900)
标记
其他选择 非结合性
应用范围
其他选择 Dot Blot (DB)
Pubmed 2个引用可参考
规格 400 μL
发货至 中国 (更改)
发货时间 9至13个工作日
产品编号 yb389756
产品细节 PI3KC3 (pSer282) 抗体
免疫原 This PI3KC3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S282 of human PI3KC3.
克隆位点 RB11900
亚型 Ig
特异性 This Phospho-PI3KC3-S282 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 267~297 amino acids surrounding S282 of human PI3KC3. Patent pending.
预测反应 Mouse (Murine),Rat (Rattus),Xenopus laevis
纯化方法 This antibody is purified through a protein A column, followed by peptide affinity purification.
目标详细情况 PI3KC3 (pSer282) 抗体
背景 PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.
Synonyms: Phosphatidylinositol 3-kinase catalytic subunit type 3, PtdIns-3-kinase type 3, PI3-kinase type 3, PI3K type 3, Phosphoinositide-3-kinase class 3, Phosphatidylinositol 3-kinase p100 subunit, vps34
分子量 101549 DA
基因ID 5289
UniProt Q8NEB9
研究领域 Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Autophagy
使用细节PI3KC3 (pSer282) 抗体
应用备注 DB = 1:500
限制 仅限研究用
贮存及处理 PI3KC3 (pSer282) 抗体
状态 Liquid
浓度 0.37 mg/mL
缓冲液 PBS with 0.09 % (W/V) sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C/-20 °C
储存方法 Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
有效期 6 months