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- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 克隆性:
单克隆
- 抗体名:
Ret Proto-Oncogene (RET) (C-Term) 抗体
- 规格:
0.1ml/0.2ml
Ret Proto-Oncogene (RET)
别名 c-ret, cret, etID315074.13, ret1, wu:fd13h01, X-ret, ret-A, xret, RET, MTC1, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, PTC, RET-ELE1, RET51, RET9, c-Ret
抗原表位
其他选择 C-Term
适用
其他选择 人
宿主
其他选择 小鼠
克隆类型 (克隆位点)
单克隆 (RET01)
标记
其他选择 非结合性
Ret Proto-Oncogene (RET) (C-Term) 抗体应用范围
其他选择 Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), 免疫组织化学石蜡技术(IHC-P)
Pubmed 3个引用可参考
规格 0.5 mL
发货至 中国 (更改)
发货时间 29至35个工作日
产品编号 yb115113
产品细节
免疫原 BALB/C mice were injected with recombinant protein encoding the extreme C-terminal cytoplasmic region of the human ret oncoprotein.
克隆位点 RET01
亚型 IgG1
特异性 Reacts to Ret Oncoprotein.
Cellular Localization: Cytoplasmic.
纯化方法 Purified
目标详细情况
别名 RET
Ret Proto-Oncogene (RET) (C-Term) 抗体背景 Ret proto-oncogene encodes a cell surface glycoprotein belonging to a member of the receptor tyrosine kinase family and is located on chromosome 10q11.2. Ret is observed in several regions of the central nervous system, in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain.Synonyms: C-ret, CDHF12, Cadherin family member 12, Proto-oncogene tyrosine-protein kinase receptor ret
基因ID 5979
NCBI登录号 NP_065681
UniProt P07949
研究领域 Signaling, Kinases/Phosphatases
使用细节
应用备注 Immunohistochemistry on paraffin embedded sections: diluted of 1: 10-1: 20 in an ABC method (90 minutes at room temperature), requires hightemperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Small intestine.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理
状态 Liquid
缓冲液 Sodium azide as preservative
储存液 Sodium azide
Ret Proto-Oncogene (RET) (C-Term) 抗体注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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文献和实验challenge. Rearrangements of the RET oncogene have been proposed as a marker for papillary thyroid cancer. In this chapter, methods for the analysis of the RET oncogene in laser microdissected papillary thyroid cancer tissue are described.
Nature Aging & Cancer Cell双重磅加持:GFRAL靶点迎来黄金窗口期,三大临床路径全面提速
水平升高,从而向大脑发出令人厌恶的内分泌信号 [13]。 GFRAL/GDF-15通路在癌症相关厌食或恶病质综合征,以及肿瘤方面也有一定的潜力。一方面,癌症相关厌食或恶病质综合征是指肿瘤患者在患病过程中不可控制的体重减轻,其症状包括厌食,肌肉量和脂肪组织减少引起的体重减轻。增加这类患者的体重则能显著改善肿瘤患者的存活率。研究人员发现,GFRAL受体拮抗单克隆抗体可抑制共表达RET和GFRAL的细胞中GDF-15诱导的信号转导。在小鼠模型中,该抗体给药可防止肿瘤诱导的体重减轻 [14]。另一
of samples can be profiled in a single day. Figure 3― Oncogene mutations included in Sequenom’s OncoCarta™ Panels Panel Number of Genes Gene (# mutations
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