促进凋亡基因抗体

促进凋亡基因抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

促进凋亡基因抗体产品介绍

CIDE-B(DFF45)是凋亡信号通路中新近发现的促进凋亡的基因,在细胞凋亡中有重要的作用,有学者认为： CIDE-B在周围神经元损伤后,脊髓内CIDE-B即可表达增强,诱导神经元凋亡; 若阻断CIDE-B的表达,能有效抑制神经元的凋亡.cide-b在肿瘤方面研究也日趋增多，他的抑制可能与肿瘤的发生有关。

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45. CIDE B is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE B is expressed mainly in liver and small intestine and at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, and bone marrow.
mol wt:24kDa
Other Aliases:
cell death activator CIDE-B; cell death-inducing DFFA-like effector B; Cide-b
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