Brefeldin A

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Brefeldin A

CAS No. : 20350-15-6

MCE 国际站：Brefeldin A

产品活性：Brefeldin A (BFA) 是一种内酯抗生素，是蛋白质运输的特定抑制剂。Brefeldin A 阻断分泌蛋白和膜蛋白从内质网向高尔基体的转运。Brefeldin A 也是一种自噬 (autophagy) 和 mitophagy 抑制剂。Brefeldin A 还是一种 CRISPR/Cas9 激动剂，可抑制 HSV-1病毒，并具有抗癌活性。

研究领域：Autophagy  |  Cell Cycle/DNA Damage  |  Anti-infection

作用靶点：Autophagy  |  CRISPR/Cas9  |  Mitophagy  |  HSV  |  Antibiotic  |  Bacterial

结构分类：抗生素  |  疾病研究  |  抗癌  |  抗生素  |  疾病研究  |  抗病毒  |  抗生素  |  大环内脂类  |  结构分类

In Vitro: Brefeldin A (BFA) treatment for 15 h or 40 h, causes dramatic swelling of the Endoplasmic Reticulum (ER) and shifts its localization to the periphery of normal rat kidney (NRK) cells. Prolonged Brefeldin A treatment results in marked disruption of the MT and actin cytoskeleton. ADP-ribosylation of BARS is mediated by formation of a conjugate between Brefeldin A and ADPR. BARS shows BAC binding when incubated with the medium from the BFA-treated CD38⁺ HeLa cells. Brefeldin A induces anchorage-independent cell death in MDA-MB-231 breast cancer cells, inhibits the formation of MDA-MB-231 colonies in 3D and 2D cultures and inhibits the migration and MMP 9 (Matrix Metallopeptidase 9) activity of MDA-MB-231.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Macrocyclic Compound Library  |  Antibacterial Compound Library  |  Medicine Food Homology Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Antibiotics Library  |  Anti-Breast Cancer Compound Library  |  Microbial Metabolite Library  |  Mitochondria-Targeted Compound Library  |  Anti-Cancer Natural Product Library  |  Antiviral Traditional Chinese Medicine Active Compound Library  |  Cysteine Targeted Covalent Library  |  Mitochondrial Toxicity Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  Myricetin 3-O-α-L-arabinopyranoside  |  (1R,2S,7R)-Sitafloxacin-d₄ hydrochloride  |  Nebacumab  |  Doxorubicin-¹³C,d₃ TFA  |  Gepotidacin  |  Amycolatopsin A  |  Antibiotic A-33853  |  Estradiol hemihydrate  |  Sulbactam-d₂ sodium  |  Antimicrobial agent-5  |  NBTIs-IN-4  |  Proanthocyanidins  |  Anticancer agent 120  |  Azlocillin sodium salt  |  Antitubercular agent-13  |  Toyocamycin  |  Lenampicillin hydrochloride  |  Hispolon  |  PC58538  |  SPR206 acetate  |  Caracemide  |  Antimicrobial agent-10  |  Doxycycline calcium  |  Antibacterial agent 138  |  Staurosporine  |  Dihydrostreptomycin sulfate  |  Ciclopirox olamine  |  Rubropunctamine  |  Curcumin  |  Topoisomerase IV inhibitor 2

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。