Fetuin-A / FetuinA / AHSG抗体

Fetuin-A / FetuinA / AHSG抗体产品信息

免疫原 :
Recombinant human Fetuin-A protein ( Catalog #10318-H08H )
抗体类型: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
1
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human Fetuin-A / AHSG ( rh Fetuin-A; Catalog#10318-H08H; NP_001613.2; Met 1- Val 367 )
Fetuin-A / FetuinA / AHSG抗体背景综述
Human Fetuin-A, also known as α2-Heremans-Schmid glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is expressed and secreted mainly by the cell source hepatocytes, and can be found at high levels in the serum as a growth promoter. As an antagonist of transforming growth factor-beta1 (TGF-β1), fetuin-A blocks TGF-beta1 binding to cell surface receptors, suppresses TGF-beta signal transduction and epithelial-mesenchymal transition, suggesting that the systemic fetuin A is closely associated with tumor progression and resistance to chemotherapy in established cancers, as well as host immune suppression. Accordingly, therapeutic enhancement of AHSG levels may benefit patients whose tumors are driven by TGF-beta. It has been shown that fetuin A inhibits both insulin receptor autophosphorylation and undesirable calcification, and plays a role in bone development, calcium homeostasis, regulation of soft tissue calcification, and insulin sensitivity.
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