Sclerostin / SOST抗体

Sclerostin / SOST抗体产品信息

免疫原 :
Recombinant human Sclerostin protein ( Catalog#10593-H07H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human Sclerostin ( rh Sclerostin; Catalog#10593-H07H; NP_079513.1 ; Gln 24 - Tyr 213 ). Sclerostin specific IgG was purified by human Sclerostin affinity chromatography.
Sclerostin / SOST抗体 Background
Sclerostin, also known as SOST, is a glycoprotein with a signal peptide for secretion and a C-terminal cysteine knot-like (CTCK) domain and belongs to the Cerberus/DAN family of bone morphogenetic protein (BMP) antagonists including Dan, Cerberus, Gremlin, PRDC, and Caronte. Sclerostin is expressed at significant levels in bone, cartilage, kidney, and liver, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. Recent studies have revealed that Sclerostin inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupts the Wnt signaling. Loss-of-function mutations of Sclerostin are associated with sclerosteosis which is an autosomal-recessive bone dysplasia characterized by progressive skeletal overgrowth, and reduced sclerostin expression results in a milder form of the disorder called van Buchem disease.
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