IL2Ra / CD25抗体

IL2Ra / CD25抗体产品信息

免疫原 :
Recombinant human IL2Ra protein ( Catalog#10165-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human IL2Ra / CD25 ( rh IL2Ra; Catalog#10165-H08H ; NP_000408.1; Met 1- Cys 213 ). IL2Ra specific IgG was purified by human IL2Ra affinity chromatography.
IL2Ra / CD25抗体背景综述
Human interleukin 2 receptor alpha (IL2Rα), also known as CD25 molecule, is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2Rα is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2Rα is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. Accordingly, IL2 receptor complex mediates the IL2 effects via regulating T cell proliferation, activation and other lymphoid functions, and IL2Rα has been shown to deliver IL2 to the signaling complex and act as a regulator of signal transduction. In addition, IL2 induces IL2R transcription via an IL2-responsive enhancer, and IL2R also inhibits IL2 gene expression by activating the expression of CTLA-4 or FOXP3 via the negative feedback loops.
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