EPOR 抗体

EPOR 抗体产品信息

免疫原 :
Recombinant Human EPOR Protein (Catalog#10707-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human EPOR (rh EPOR; Catalog#10707-H08H; NP_000112.1; Met 1-Pro 250). EPOR specific IgG was purified by Human EPOR affinity chromatography.
EPOR 抗体Background
Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. Mouse EPOR contains a tryptophan-serine-X-tryptophan-serine (WSXWS) motif and 1 copy of a cytoplasmic immunoreceptor tyrosine-based inhibitor motif (ITIM) motif, and shares approximately 80% amino acid sequence identity with the human EPOR. Mouse EPOR is expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells. EPO binding to EPOR triggers auto- or trans-phosphorylation of a protein-tyrosine kinase JAK2 bound to the receptor cytosolic (CT) domain, and subsequently JAK2 activates a variety of intracellular signal substrates including Ras/MAPK, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to function in erythroid cell survival through preventing the PCD, and is also suggested to play a neuroprotective role for its expression in mammalian brains.
EPOR 抗体相关产品如下：
hz-4271R ARHGAP20Rho GTP酶激活蛋白20抗体
hz-4653R ASB10含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体
hz-5709R ALDH1L1乙醛脱氢酶1蛋白家族L1抗体
hz-5717R Axin 2轴抑制蛋白2抗体
hz-7027R ANGPTL6血管生成素相关蛋白6抗体
hz-4687R AMHMuellerian缪勒管激素抑制因子抗体
hz-7035R EphA8酪氨酸蛋白激酶受体A8抗体
hz-11383R Acetoacetyl-CoA synthetase脂肪酰辅酶A家族成员1抗体
hz-11446R ARNTL2芳香烃受体核转录蛋白样2抗体
hz-11448R phospho-AANAT (Thr29)磷酸化芳香胺N-乙酰化转移酶抗体
hz-11449R ABLIM1肌动蛋白结合蛋白1抗体
hz-11450R AMIGO2粘附分子IgG样结构域蛋白2抗体
hz-11451R Advillin肌动蛋白结合蛋白DOC6抗体
hz-11704R AFG3L2AFG3样蛋白2/脊髓小脑共济失调蛋白28抗体
hz-11705R AIP1激活素受体相互作用蛋白1抗体
hz-11706R AKR7A2醛固酮类还原酶家族7成员A2抗体
hz-6951R AKT1+2+3蛋白激酶AKT1,2,3抗体
hz-11708R ATP13A2帕金森病相关蛋白ATP13A2抗体
hz-11709R ALS2肌萎缩侧索硬化蛋白2抗体
hz-11707R phospho-ATM (Tyr170)磷酸化毛细血管扩张性共济失调症突变蛋白抗体
hz-10150R ACADL酰基辅酶A脱氢酶长链抗体
hz-7778R APC5细胞分裂周期蛋白5抗体
hz-0076R beta-Amyloid 1-42(CT)β淀粉样肽/Aβ42抗体
hz-8070R ADCK4ADCK4蛋白抗体
hz-7892R AIMP3抑癌蛋白AIMP3抗体
hz-7903R AKAP associated Sperm Protein精子相关蛋白AKAP抗体
hz-7904R AKAP6蛋白激酶A锚定蛋白6抗体
hz-7942R ABHD1肺α/β水解酶蛋白1抗体
hz-7943R ABHD13水解酶结构域蛋白13抗体
hz-7945R ABHD14B水解酶结构域蛋白14B抗体
hz-7946R ABHD15水解酶结构域蛋白15抗体
hz-7947R ABHD3肺α/β水解酶蛋白3抗体
hz-7941R ABCF3三磷酸腺苷结合盒转运蛋白F亚基3抗体
hz-7940R ABCA5三磷酸腺苷结合盒转运蛋白A亚基5抗体
hz-7951R ADCK1ADCK1蛋白抗体
hz-7950R ACBD4酰基辅酶A结合结构域蛋白4抗体
hz-7948R ABHD4α/β水解酶4抗体
hz-7952R ADCK2ADCK2蛋白抗体
hz-7956R ALDH16A1乙醛脱氢酶16家庭A1抗体
hz-7959R AMIGO3粘附分子IgG样结构域蛋白3抗体
hz-7953R AKR1A1乙醇脱氢酶1抗体
hz-7954R ALADδ氨基乙酰丙酸脱水酶抗体
hz-7958R ALS2CR4肌萎缩侧索硬化症相关蛋白4抗体
hz-9505R alpha 2 Macroglobulinα2巨球蛋白(α-2M)抗体
hz-9062R ACCSLACCSL蛋白抗体
hz-4708R AFP甲胎蛋白抗体
hz-11058R Mint3β淀粉样前体蛋白结合蛋白3抗体
hz-11072R ASTN2星形肌动蛋白抗体
hz-11223R TREX1系统性红斑狼疮相关蛋白TREX1抗体