CES2 / Carboxylesterase 2抗体

CES2 / Carboxylesterase 2抗体产品信息

免疫原 :
Recombinant Human CES2 / Carboxylesterase 2 protein (Catalog#10380-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human CES2 / Carboxylesterase 2 (rh CES2 / Carboxylesterase 2; Catalog#10380-H08H; O00748-1; Met 1-Leu 559). CES2 / Carboxylesterase 2 specific IgG was purified by Human CES2 / Carboxylesterase 2 affinity chromatography.
CES2 / Carboxylesterase 2抗体Background
Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Mouse carboxylesterase 2, also known as CES2, is a endoplasmic reticulum lumen protein which belongs to thetype-B carboxylesterase / lipase family. CES2 is preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression of CES2 is found in small intestine with lower expression in colon and rectum. CES2 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES2 shows high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.
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