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- CST
- 中国/美国/德国
- hz-10817-RP02
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
APOE / apolipoprotein E抗体
免疫原 :
Recombinant Human APOE / apolipoprotein E protein (Catalog#10817-H30E)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human APOE / apolipoprotein E (rh APOE / apolipoprotein E; Catalog#10817-H30E; P02649; Lys 19-His 317). APOE / apolipoprotein E specific IgG was purified by Human APOE / apolipoprotein E affinity chromatography.
APOE / apolipoprotein E抗体 Background
Apolipoprotein E (ApoE) is a 34.2 kDa glycosylated protein with 299 amino acid residues. ApoE is synthesized predominantly in the liver. Hepatic parenchyma cells are the main apoE producing cells in mammalian body, probably accounting for two thirds to three fourths of the plasma apoE. In the nervous system, apoE mRNA is present in neurons, astrocytes, ependymal cells, nonmyelinating Schwann cells. ApoE/Apolipoprotein E produced by mammalian cells exists in different forms, monomers, dimers, modified, unmodified, lipid-rich, and lipid-poor, and so forth. ApoE/Apolipoprotein E plays a double-role in immune responses. Both ApoE/Apolipoprotein E containing lipoproteins and multimers of synthetic apoE peptides inhibited proliferation of cultured lymphocytes by inhibiting DNA synthesis and reducing phospholipid turnover in T cells. ApoE/Apolipoprotein E can also affect innate and acquired immune responses in vitro by its ability to suppress stimulation of cultured neutrophils. ApoE/Apolipoprotein E can bind lipopolysaccharide (LPS), attenuate the inflammatory response, and thus reduce LPS induced lethality. Injection of LPS stimulated higher expression of inflammatory cytokines like interleukin (IL)-1, IL-12, and interferon-γ (IFN-γ), as well as IL-6.
APOE / apolipoprotein E抗体相关产品如下：
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hz-8221R FAM153BFAM153B蛋白抗体
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hz-8206R RMD2微管动力调节蛋白2抗体
hz-8208R FAM50AFAM50A蛋白抗体
hz-8213R FAM113AFAM113A蛋白抗体
hz-8219R FAM150AFAM150A蛋白抗体
hz-8240R FRMD8FRMD8蛋白抗体
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hz-8194R FAM40AFAM家族蛋白40A抗体
hz-8196R FAM55DFAM55D蛋白抗体
hz-8195R FAM120B组织激活过氧化酶活化增生受体γ蛋白抗体
hz-8214R FAM21CFAM21C蛋白抗体
hz-8215R FAM13C1FAM13C1蛋白抗体
hz-8217R FAM59BFAM59B蛋白抗体
hz-8218R FAM59AFAM59A蛋白抗体
hz-8225R FAM160B1FAM160B1蛋白抗体
hz-8226R FAM161BFAM161B蛋白抗体
hz-8220R FAM151AFAM151A蛋白抗体
hz-8224R FAM156A跨膜蛋白29抗体
hz-8222R FAM154AFAM154A蛋白抗体
hz-8223R FAM155AFAM155A蛋白抗体
hz-8227R FAM164BFAM164B蛋白抗体
hz-8234R FRMD3FRMD3蛋白抗体
hz-8236R FRMD4BFRMD4B蛋白抗体
hz-8239R FRMD7FRMD7蛋白抗体
hz-8235R FRMD4AFRMD4A蛋白抗体
hz-8228R FAHD2A延胡索酰乙酰乙酸水解酶抗体
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hz-8230R FAM102BFAM102B蛋白抗体
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hz-6381R FAM107A肾细胞癌下调蛋白1抗体
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hz-9595R FOLR2胎盘叶酸受体蛋白2抗体
hz-5757R FAM13B1FAM13B1蛋白抗体
hz-6280R FUT8岩藻糖转移酶8抗体
hz-13193R FNIP1卵泡刺激素结合蛋白1抗体
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文献和实验Apolipoprotein E Expression and Purification
Since the discovery of the association of apolipoprotein E (apoE) 4 with Alzheimer’s disease 17 years ago, numerous in vitro experiments with the apoE isoforms (apoE2, apoE3, and apoE4) have been performed to try to understand the basis
APOE-Based Models of Pre-Dementia
Producing a valid animal model of apolipoprotein E (APOE )-based dementia is critical to understanding the etiology and progression of late-onset Alzheimer’s disease (AD). Unfortunately, no such model exists. Herein, I review
8.16 衰老可以逆转？Nature最新发现逆转脑干细胞的衰老过程！
（apoE，apolipoprotein E）或能促进乙肝病毒感染和产生，相关研究结果发表在国际杂志 PLoS Pathogens 上。这项研究中，研究者发现，apoE 能够促进乙肝病毒感染和产生，apoE 在丙肝病毒感染过程中扮演着关键角色，在乙肝病毒中研究者发现了大量人类 apoE 蛋白，而且其会整合到病毒的包膜中，利用 apoE 特异性单克隆抗体或通过沉默 apoE 的表达及敲除 apoE 基因，都能够有效阻断乙肝病毒的感染。此外，下调 apoE 基因的表达或敲除携带乙肝病毒的肝脏
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