LAIR2 / CD306抗体

LAIR2 / CD306抗体产品信息

免疫原 :
Recombinant human LAIR2 protein ( Catalog#10868-H08H)
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human LAIR2 ( rhLAIR2; Catalog #10868-H08H; NP_002279.2; Met 1-Pro 152 ). Total IgG was purified by Protein A affinity chromatography.
LAIR2 / CD306抗体Background
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2), also known as CD306, is a protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.
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