SIRPA / CD172A抗体

SIRPA / CD172A抗体产品信息

免疫原 :
Recombinant human SIRPA protein ( Catalog#11612-H08H )
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
03
抗体宿主 :
Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human SIRPA ( rh SIRPA ; Catalog#11612-H08H ; NP_542970.1 ; Met 1 - Arg 370 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
SIRPA / CD172A抗体背景综述
Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
SIRPA / CD172A抗体相关产品如下：
hz-9992R C4orf144号染色体开放阅读框14抗体
hz-9552R CXorf21X染色体开放阅读框21抗体
hz-11275R phospho-CTBP1 (Ser422)磷酸化C端结合蛋白1抗体
hz-11078R Cadherin 8钙粘附蛋白8抗体
hz-9530R C6orf1928号染色体开放阅读框192抗体
hz-9982R C21orf8721号染色体开放阅读框87抗体
hz-9983R C21orf9121号染色体开放阅读框91抗体
hz-9984R C22orf2522号染色体开放阅读框25抗体
hz-9699R C20orf19620号染色体开放阅读框196抗体
hz-9483R C5orf355号染色体开放阅读框35抗体
hz-9697R C20orf19420号染色体开放阅读框194抗体
hz-9995R C4orf324号染色体开放阅读框32抗体
hz-15199R C5orf20 5号染色体开放阅读框20抗体
hz-9215R Cystatin D胱抑素D/半胱氨酸蛋白酶抑制剂D抗体
hz-9216R CST8胱抑素8/半胱氨酸蛋白酶抑制剂8抗体
hz-9217R CST9胱抑素9/半胱氨酸蛋白酶抑制剂9抗体
hz-9218R Cystatin S胱抑素S/半胱氨酸蛋白酶抑制剂S抗体
hz-6455R CHRNA3型乙酰胆碱受体α3抗体
hz-9828R C3orf333号染色体开放阅读框33抗体
hz-9830R C3orf393号染色体开放阅读框39抗体
hz-9833R C3orf593号染色体开放阅读框59抗体
hz-9484R C5orf515号染色体开放阅读框51抗体
hz-9884R C3orf703号染色体开放阅读框70抗体
hz-9810R C2orf682号染色体开放阅读框68抗体
hz-9811R C2ORF472号染色体开放阅读框47抗体
hz-4826R CD83CD83抗体
hz-9838R C17orf5917号染色体开放阅读框59抗体
hz-9839R C17ORF3917号染色体开放阅读框39抗体
hz-8524R Calcium Sensing Receptor钙敏感受体1抗体
hz-4902R Calponin 1 + 2 + 3钙结合蛋白Calponin抗体
hz-9814R C2orf442号染色体开放阅读框44抗体
hz-9817R C2orf552号染色体开放阅读框55抗体
hz-9818R C2orf572号染色体开放阅读框57抗体
hz-9821R C2orf292号染色体开放阅读框29抗体
hz-9826R C3orf213号染色体开放阅读框21抗体
hz-9792R C1ORF741号染色体开放阅读框74抗体
hz-9793R C1QTNF10补体C1q和肿瘤坏死因子相关蛋白10抗体
hz-9794R C1orf931号染色体开放阅读框93抗体
hz-9795R C1orf941号染色体开放阅读框94抗体
hz-9796R C1orf961号染色体开放阅读框96抗体
hz-9798R C1orf411号染色体开放阅读框41抗体
hz-9799R C1orf1441号染色体开放阅读框144抗体
hz-15191R C4orf34号染色体开放阅读框3抗体
hz-8558R Cathepsin S组织蛋白酶S抗体
hz-7605R Cell death inducing protein细胞死亡诱导蛋白抗体
hz-7603R Cipar1前列腺雄激素抑制信号蛋白1抗体
hz-9860R phospho-cardiac Troponin I (Thr143)磷酸化心肌肌钙蛋白抗体
hz-11126R PVRL1脊髓灰质炎受体相关蛋白1抗体
hz-13796R C19orf7319号染色体开放阅读框73抗体
hz-11127R CD11b整合素αM抗体Integrin αM
hz-11128R CASPR轴突蛋白4/少突胶质细胞抗体