Endoglin / ENG抗体

Endoglin / ENG抗体产品信息

免疫原 :
Recombinant human CD105 protein ( Catalog#10149-H08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human Endoglin / CD105 ( rh CD105 ; Catalog#10149-H08H ; NP_001108225.1 ; Met 1 - Gly 586 ). CD105 specific IgG was purified by human CD105 affinity chromatography.
Endoglin / ENG抗体背景综述
Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Endoglin contains an RGD tripeptide, a key recognition structure in cellular adhesion, and suggests a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathway. In addition, ALK-1 is also a receptor kinase in human umbilical vein endothelial cells for endoglin threonine phosphorylation, and mutations in either result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful marker of neovascularization, and associated with several solid tumor types.
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