Rat PVR / CD155抗体

Rat PVR / CD155抗体产品信息

免疫原 :
Recombinant Rat CD155 protein ( Catalog#80007-R08H )
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
4F10H8A11
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant rat PVR ( rR PVR ; Catalog#80007-R08H ; NP_058772.2 ; Met 1 - Gly 352 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
Rat PVR / CD155抗体背景综述
Rat PVR (poliovirus receptor), also known as CD155 and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein. PVR / CD155 belongs to the nectins and nectin-like (Necl) subfamily of immunoglobulin superfamily. This protein contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. PVR / CD155 is predominately expressed by enterocytes and cells of gastrointestinal lymphatic tissues and originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function of CD155 maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the CD155 mRNA yields four different isoforms(α, β, γ, and δ) with the identical extracellular domains. CD155-β and –γ are secreted, whereas the membrane-bound CD155-α and -δ serve as PV receptors. In addition, it has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
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