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- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
PD-L2 / CD273 / B7-DC抗体
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human PD-L2 / CD273 ( rh PD-L2 ; Catalog#10292-H08H; NP_079515.2; Met 1- Pro 219 ). Total IgG was purified by Protein A affinity chromatography.
PD-L2 / CD273 / B7-DC抗体背景综述
Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. It has been demonstrated that on human T cells, PD-L2 acts only as a negative regulator of T cell activity by inhibiting T-cell proliferation and cytokine production, involving modulation of the PI3-K/AKT and ERK/ MAPK pathways.
PD-L2 / CD273 / B7-DC抗体相关产品如下：xy-0358M-xyy3 Mouse Anti-Guinea pig IgG/Cy3Cy3标记的小鼠抗豚鼠IgG
xy-0358M-xyy5 Mouse Anti-Guinea pig IgG/Cy5Cy5标记的小鼠抗豚鼠IgG
xy-0358M-xyy5.5 Mouse Anti-Guinea pig IgG/Cy5.5Cy5.5标记的小鼠抗豚鼠IgG
xy-0358M-xyy7 Mouse Anti-Guinea pig IgG/Cy7Cy7标记的小鼠抗豚鼠IgG
xy-0358M-xyE Mouse Anti-Guinea pig IgG/PEPE标记的小鼠抗豚鼠IgG
xy-0358M-xyE-xyy3 Mouse Anti-Guinea pig IgG/PE-Cy3PE-Cy3标记的小鼠抗豚鼠IgG
xy-0358M-RBITxy Mouse Anti-Guinea pig IgG/RBITC罗丹明标记的小鼠抗豚鼠IgG
xy-0312R-RBITxy Rabbit Anti-Avidin/RBITC罗丹明标记的兔抗亲和素
xy-0312R-FITxy Rabbit Anti-Avidin/FITCFITC标记的兔抗亲和素
xy-0312R-Axy Rabbit Anti-Avidin/AP碱性磷酸酶（AP）标记的兔抗亲和素
xy-0312R-Golxy Rabbit Anti-Avidin/Gold胶体金标记的兔抗亲和素
xy-0312R-HRxy Rabbit Anti-Avidin/HRP辣根过氧化物酶标记的兔抗亲和素
xy-0312R-xyy5.5 Rabbit Anti-Avidin/Cy5.5Cy5.5标记的兔抗亲和素
xy-0312R-xyy7 Rabbit Anti-Avidin/Cy7Cy7标记的兔抗亲和素
xy-0312R-xyE Rabbit Anti-Avidin/PEPE标记的兔抗亲和素
xy-0312R-xyy3 Rabbit Anti-Avidin/Cy3Cy3标记的兔抗亲和素
xy-0312R-xyy5 Rabbit Anti-Avidin/Cy5Cy5标记的兔抗亲和素
xy-0312R-Bio Rabbit Anti-Avidin/Bio生物素标记的兔抗亲和素
xy-0312R-xyE-xyY5 Rabbit Anti-Avidin/PE-CY5PE-CY5标记的兔抗亲和素
xy-0312R-Axyxy Rabbit Anti-Avidin/APCAPC标记的兔抗亲和素
xy-0312R-AF350 Rabbit Anti-Avidin/Alexa Fluor 350Alexa Fluor 350标记的兔抗亲和素
xy-0312R-AF488 Rabbit Anti-Avidin/Alexa Fluor 488Alexa Fluor 488标记的兔抗亲和素
xy-0312R-AF555 Rabbit Anti-Avidin/Alexa Fluor 555Alexa Fluor 555标记的兔抗亲和素
xy-0312R-AF647 Rabbit Anti-Avidin/Alexa Fluor 647Alexa Fluor 647标记的兔抗亲和素
xy-0312R-xyE-xyy5.5 Rabbit Anti-Avidin/PE-Cy5.5PE-Cy5.5标记的兔抗亲和素
xy-0312R-xyE-xyy7 Rabbit Anti-Avidin/PE-Cy7PE-Cy7标记的兔抗亲和素
xy-0311R-xyy3 Rabbit Anti-Biotin/Cy3Cy3标记的兔抗生物素抗体IgG
xy-0311R-xyy5 Rabbit Anti-Biotin/Cy5Cy5标记的兔抗生物素抗体IgG
xy-0311R-xyy5.5 Rabbit Anti-Biotin/Cy5.5Cy5.5标记的兔抗生物素抗体IgG
xy-0311R-xyy7 Rabbit Anti-Biotin/Cy7Cy7标记的兔抗生物素抗体IgG
xy-0311R-xyE Rabbit Anti-Biotin/PEPE标记的兔抗生物素抗体IgG
xy-0311R-xyE-xyy3 Rabbit Anti-Biotin/PE-Cy3PE-Cy3标记的兔抗生物素抗体IgG
xy-0311R-xyE-xyY5 Rabbit Anti-Biotin/PE-CY5PE-CY5标记的兔抗生物素抗体IgG
xy-0311R-Axyxy Rabbit Anti-Biotin/APCAPC标记的兔抗生物素抗体IgG
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文献和实验了 B7 家族的第三个成员 B7-H1（即日后的 PD-L1）[2]。2000 年，Tasuku Honjo 教授等人证明了 PD-L1 能与 PD-1 结合，进而抑制 T 细胞的增殖与细胞因子的分泌，负调控淋巴细胞的激活，从此，B7-H1 被正式命名为 PD-L1（陈列平教授则继续使用「B7-H1」命名）[3]。2003年，陈列平教授第一次成功地使用 PD-L1 封闭抗体联合 T 细胞回输技术治愈了约 60% 的头颈癌小鼠[4]。2014 年 12 月，首个应用于肿瘤治疗的抗 PD-1 抗体
Gene Therapy of X-Linked Severe Combined Immunodeficiency
to transduce ex vivo the CD34+cells of patients. This gene therapy protocol is currently being applied and the encouraging preliminary results published (1 ). The success of this protocol could be mainly attributed to the physiopathology of the SCID-X1 disease
HIV的生物学标志之X4病毒株是检验技师考试中所包含的内容。医学教育网收集整理了部分相关信息供学员参考。 10月15日出版的《传染病杂志》上，一篇文章报道，HIV-1亚型B变异通过CXCR4（X4病毒）感染细胞，经常出现CD4+T细胞数量高，可能会导致晚期HIV-1感染过程中T细胞数量快速减少。 报道叙述了美国研究者进行的一项分析研究，他们的资料来自多中心艾滋病群体研究（MACS），这是一项几个主要城区近七千同性恋男性参加的纵向研究。因为样本选择接近流行
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