KLK13抗体

KLK13抗体产品信息

免疫原 :
Recombinant human KLK13 protein ( Catalog #10199-H08H )
克隆号 :
10H10A2C4
抗体宿主 :
Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human KLK13 / Kallikrein13 (rhKLK13; Catalog#10199-H08H; NP_056411.1; Met 1- Ile 262). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
KLK13抗体背景综述
Human tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4) and KLK13 is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like, secreted serine protease expressed specifically in the testicular tissue including prostate, salivary gland, breast, and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.
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