Dkk1 / Dickkopf-1抗体

Dkk1 / Dickkopf-1抗体产品信息

免疫原 :
Recombinant human Dkk1 protein ( Catalog #10170-H08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
004
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human dickkopf related protein 1 ( rh Dkk1 ; Catalog #10170-H08H ; Met 2 – His 266 ; NP_036374.1 ).
Dkk1 / Dickkopf-1抗体Background
DKK1 ( dickkopf related protein 1 ) is a head inducer secreted from the vertebrate head organizer and belongs to the DKK protein family including four members. DKK1 is synthesized initially as a precursor protein with an N-terminal signal peptide and two cysteine-rich domains. DKK proteins have distinct patterns of expression in adult and embryonic tissues and have effects on Wnt signaling implicated in diverse processes. Dkk1 is a specific and high-affinity ligand for LRP6 ( LDL-receptor-related protein 6 ) acting as a Wnt co-receptor. Dkk1 blocks LRP6-mediated Wnt/beta-catenin signaling by antagonistically inhibiting the formation of Wnt-Fz-LRP6 complex which triggers the Wnt signal pathway. It is revealed that Wnt signaling in osteoblasts is necessary to promote BMP-2-mediated differentiation of pre-osteoblast cells, and therefore, DKK1 may play a key role in regulating pre-osteoblast differentiation and the development of multiple myeloma-associated osteolytic bone lesions.
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