4E-BP1 / EIF4EBP1抗体

4E-BP1 / EIF4EBP1抗体产品信息

免疫原 :
Recombinant Human 4E-BP1 / EIF4EBP1 protein (Catalog#10022-H07E)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
058
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human 4E-BP1 / EIF4EBP1 (rh 4E-BP1 / EIF4EBP1; Catalog#10022-H07E; NP_004086.1; Ser 2-Ile 118).
4E-BP1 / EIF4EBP1抗体Background
Eukaryotic translation initiation factor 4E-binding protein 1, also known as Phosphorylated heat- and acid-stable protein regulated by insulin 1, 4E-BP1, eIF4E-binding protein 1 and EIF4EBP1, belongs to theeIF4E-binding protein family. EIF4EBP1 / 4E-BP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. It mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Nonphosphorylated EIF4EBP1 / 4E-BP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. Insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. It interacts with RPTOR as well. Endoplasmic reticulum (ER) stress-mediated apoptosis may play a crucial role in loss of pancreatic beta cell mass, contributing to the development of diabetes. Induction of EIF4EBP1 / 4E-BP1, the suppressor of the mRNA 5' cap-binding protein eukaryotic initiation factor 4E (eIF4E), is involved in beta cell survival under ER stress. EIF4EBP1 / 4E-BP1 induction contributes to the maintenance of beta cell homeostasis during ER stress and is a potential therapeutic target for diabetes.
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