4E-BP1 / EIF4EBP1抗体

4E-BP1 / EIF4EBP1抗体产品信息免疫原 : Recombinant Human 4E-BP1 / EIF4EBP1 protein (Catalog#10022-H07E)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 058

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human 4E-BP1 / EIF4EBP1 (rh 4E-BP1 / EIF4EBP1; Catalog#10022-H07E; NP_004086.1; Ser 2-Ile 118).
4E-BP1 / EIF4EBP1抗体 Background
Eukaryotic translation initiation factor 4E-binding protein 1, also known as Phosphorylated heat- and acid-stable protein regulated by insulin 1, 4E-BP1, eIF4E-binding protein 1 and EIF4EBP1, belongs to theeIF4E-binding protein family. EIF4EBP1 / 4E-BP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. It mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Nonphosphorylated EIF4EBP1 / 4E-BP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. Insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. It interacts with RPTOR as well. Endoplasmic reticulum (ER) stress-mediated apoptosis may play a crucial role in loss of pancreatic beta cell mass, contributing to the development of diabetes. Induction of EIF4EBP1 / 4E-BP1, the suppressor of the mRNA 5' cap-binding protein eukaryotic initiation factor 4E (eIF4E), is involved in beta cell survival under ER stress. EIF4EBP1 / 4E-BP1 induction contributes to the maintenance of beta cell homeostasis during ER stress and is a potential therapeutic target for diabetes.
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xy-0832xy MICA(MHC class I polypeptide-related sequence A)一种细胞应激分子抗原
xy-0656xy MRP3(Multidrug Resistanec-Associated Protein 3)多药耐药相关蛋白3(抗原)
xy-0657xy MRP1(Multidrug Resistanec-Associated Protein 1)多药耐药相关蛋白1(抗原)
xy-0661xy LRP/MVP (Lung resistance related protein)肺耐药相关蛋白(抗原)
xy-0300xy MSLN(mesothelin)间皮素(多肽抗原)
xy-0758xy MSH2 (mutS homolog 2)MSH2抗原
xy-0453xy NKR(Neuromedin B Receptor)神经激肽B受体（抗原）
xy-0707xy NF-L(Neurofilament triplet L)低分子量神经丝蛋白（抗原）
xy-0710xy NF-M (Neurofilament triplet M)中分子量神经丝蛋白（抗原）
xy-0708xy NF-H(Neurofilament triplet H)高分子量神经丝蛋白(抗原)
xy-0448xy NIS(Na+/I-symporter;NIS)钠碘转运体蛋白（多肽抗原）
xy-0465xy NFKBp65(p65 NF-kappa B;p65NFKB)细胞核因子或称k基因结合核因子(多肽抗原)
xy-0323xy NR2A (Glutamate receptor2A)谷氨酸受体（N端抗原）
xy-0693xy NRP-1(neuropilin-1)神经纤毛蛋白-1(抗原)
xy-0694xy NRP-2(neuropilin-2)神经纤毛蛋白-2（抗原）
xy-0700xy NSBP1(Nucleosome-binding protein 1)核小体结合蛋白1(抗原)
xy-0046xy NTP，Neurual thread protein神经丝蛋白（抗原）
xy-0606xy OAT-1 (Organic anion transporter 1)human阴离子转运蛋白-1(人源）
xy-0607xy OAT-1 (Organic anion transporter 1)mouse、rat阴离子转运蛋白-1（大、小鼠同源：人源见bs-0606P）
xy-0609xy OAT-3(Organic anion transporter 3)阴离子转运蛋白-3(抗原)
xy-0604xy galectin 9 半乳糖凝集素9（抗原）
xy-0830xy Oct-4胚胎干细胞关键蛋白(多肽)
xy-0026xy OPN(osteopontin)骨桥蛋白（抗原）
xy-0740xy P16/CDKN2A (Cyclin-dependent kinase inhibitor-2A)抑癌基因p16（抗原）
xy-0741xy p21/WAF1/CIP1 p21 核分裂抑制因子之一（抗原）
xy-0742xy p27 (cyclin-dependent kinase inhibitor 1B)p27(抗原)
xy-0723xy P63 proteinP63 肿瘤抑制基因（抗原）
xy-0431xy OPG(Osteoprotegerin)护骨素(多肽抗原)
xy-0747xy OPGL (Osteoprotegerin ligand)骨保护蛋白配体(抗原)
xy-0427xy P311 protein增生性瘢痕相关蛋白（抗原）
xy-0769xy PARP(poly ADP-ribose polymerase)多腺苷二磷酸多聚酶抗原