TRAIL R2 / TNFRSF10B / CD262抗体

TRAIL R2 / TNFRSF10B / CD262抗体产品信息免疫原 : Recombinant Human TRAIL R2 / TNFRSF10B / CD262 protein (Catalog#10465-H08H)

Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID : 102

抗体宿主 : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R2 / TNFRSF10B / CD262 (rh TRAIL R2 / TNFRSF10B / CD262; Catalog#10465-H08H; NP_003833.3; Met 1-Glu 182) and conjugated with PE under optimum conditions, the unreacted PE was removed.
TRAIL R2 / TNFRSF10B / CD262抗体 Background
TRAILR2, also known as DR5 and TNFRSF10B, is the fifth death domain-containing member of the TNFR family and a receptor for TRAIL/TNFSF10. TRAILR2 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a predicted hydrophobic transmembrane segment and a 209 aa long cytoplasmic tail containing a typical "death domain". Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor TNFRSF10B. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. TRAIL-R2 exhibits high structural and functional homology to TRAIL-R1 (DR-4), and TNFRSF10B expression is regulated by the tumor suppressor p53. Further, it is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
TRAIL R2 / TNFRSF10B / CD262抗体相关产品如下：xy-8390R SHFM3SHFM3蛋白抗体
xy-8329R SRXN1硫氧还蛋白1抗体
xy-7878R STAM信号转导衔接蛋白1抗体
xy-5332R phospho-SLK (Tyr530)磷酸化酪氨酸蛋白激酶Fyn/同步原癌基因抗体
xy-9027R SPTLC2丝氨酸棕榈酰转移酶2抗体
xy-5616R Phospho-Smad3 (Ser425)磷酸化细胞信号转导分子SMAD3抗体
xy-5617R Phospho-Smad3 (Ser208)磷酸化细胞信号转导分子SMAD3抗体
xy-5618R Phospho-Smad2(Thr220)磷酸化细胞信号转导分子SMAD2抗体
xy-5627R phospho-Alpha synuclein (Tyr125)磷酸化核突触蛋白α抗体
xy-5628R phospho-Alpha synuclein(Ser129)磷酸化核突触蛋白α抗体
xy-5630R phospho-SYN1(Ser549)磷酸化神经突触素1抗体
xy-5631R phospho-SYN1(Ser603) 磷酸化神经突触素1抗体
xy-5632R phospho-SYN1(Ser62+Ser67)磷酸化神经突触素1抗体
xy-5639R phospho-STXBP1 (Ser515)磷酸化神经突触前膜胞内蛋白抗体
xy-5974R SMYD3组蛋白甲基转移酶SMYD3抗体
xy-5975R SSX8滑膜肉瘤X断点蛋白8抗体
xy-5622R phospho-STAT6(Thr645)磷酸化信号转导和转录激活因子6抗体
xy-5623R Phospho-Stathmin(Ser25)磷酸化原癌基因蛋白18
xy-6257R STK38丝氨酸/苏氨酸蛋白激酶38抗体
xy-2945R SNX1分选连接蛋白1抗体
xy-6159R STARD8GTP酶激活因子STARD8抗体
xy-6186R SERPIN A11丝氨酸蛋白酶抑制剂A11抗体
xy-6523R SCRO鳞状细胞癌相关蛋白抗体
xy-5529R S100A6S100钙结合蛋白A6抗体
xy-4146R S100A11S100钙结合蛋白A11抗体
xy-4165R S100PS100钙结合蛋白P抗体
xy-4145R SYTL5突触样蛋白5亚型2抗体
xy-5942R SERINC3丝氨酸合并蛋白3抗体（肿瘤差异表达蛋白）
xy-5945R SnoNSmad核转录共抑制因子抗体
xy-5943R SETSET易位蛋白/髓系白血病相关蛋白抗体
xy-5944R SETSET易位蛋白/髓系白血病相关蛋白抗体
xy-5957R Styk1丝氨酸/苏氨酸/酪氨酸激酶STYK1抗体
xy-6684R SCN11A钠通道蛋白11α抗体
xy-6687R SCN1B钠离子通道β1抗体