Hemopexin / HPX抗体

Hemopexin / HPX抗体产品信息

免疫原 :
Recombinant Human Hemopexin / HPX protein (Catalog#10870-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
036
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human Hemopexin / HPX (rh Hemopexin / HPX; Catalog#10870-H08H; NP_000604.1; Met 1-His 462).
Hemopexin / HPX抗体 Background
Hemopexin is a 60 kDa serum glycoprotein responsible for the transport of haem to tissues such as liver, by receptor-mediated endocytosis, in an analogous manner to the iron transport protein transferrin, with recycling of intact haemopexin. Hemopexin bindshemewith the highest affinity of any known protein. Its performs functions in scavenging the heme released or lost by the turnover of heme proteins such ashemoglobin, thus protects the body from the oxidative damage that free heme can cause. In addition, hemopexin releases its boundligandfor internalisation upon interacting with a specific receptor situated on the surface of liver cells, thus implicated in preservation of the body'siron. High hemopexin levels indicate that there has been significant degradation of heme containing compounds and hemopexin is made to scavenge any heme it can, and high hemopexin levels are therefore one of the diagnostic features of a hemolyticanemia.
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